GEORGETOWN UNIVERSITY (THE)
The Washington Metropolitan WINS (WMW) Consortium has enrolled and retained a representative cohort of HIV infected and HIV uninfected women since 1993 with the purpose of investigating the consequences of HIV infection and its treatment. Although significant progress has been made in both our understanding and treatment of HIV, curative therapy is still not available and the chronically administered complex therapies used to treat HIV are not always successful. Treatment with highly active antiretrovirals (HAART) appears to be associated with a wide range of adverse effects and the impact of other co-pathogens such as HPV and HCV has yet to be fully elucidated. Additionally, the early cohort of infected women is aging, and the effects of age and changes in sex steroids both on the long term outcomes of HIV, on neurocognition and the effects of HAART treatment needs investigation. The WMW has joined with centers around the country and with sites across the metropolitan Washington region to develop a scientific plan to address these issues. A successful and flexible infrastructure has been established to allow us to accomplish these scientific aims and to assure ongoing retention of this important cohort. The WMW has successfully participated in all elements of the WIHS protocol, and has actively supported the infrastructure of the national WIHS. WMW investigators have participated in all of the major WIHS scientific initiatives. Additionally, the WMW has established both a local specimen repository and contributes to the national specimen repository. As the study has matured, an increasing number of collaborations have been established with local investigators to allow for broader access to the rich repository of WIHS specimens. Further, the WMW has expanded its local epidemiologic expertise to allow for on site data analyses. This application will describe both our accomplishments to date and the structure that we have established to
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| AWARD OVERVIEW |
| Award Number |
3U01AI034994-17S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$1,223,446 |
Project Location - City |
Washington |
| Award Date |
06/14/2010 |
Project Location - State |
DC |
| Project Status |
More than 50% Completed |
Project Location - Zip |
20057-1789
|
| Jobs Reported |
0.00 |
Congressional District |
01 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
GEORGETOWN UNIVERSITY (THE) |
| Recipient DUNS Number |
049515844
|
| Recipient Address |
37TH & O STS NW |
| Recipient City |
WASHINGTON |
| Recipient State |
District of Columbia |
| Recipient Zip |
20057-0001 |
| Recipient Congressional District |
01 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
WASHINGTON METROPOLITAN WOMEN'S INTERAGENCY HIV STUDY |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Alliances & Advocacy |
| Quarterly Activities/Project Description |
1.Compared to HIV uninfected subjects, HIV infected subjects (Fig. 1)
1). Had reduced Ach relaxation, EDRF, EDHF (fig. 1A) and decreased NO activity and a increased contractivities, EDCF with increased ROS.
2). Plasma cytokines showed a pattern of enhanced inflammation.
3). Plasma arginine: ADMA concentration was reduced in the HIV/AIDS group (Fig. 2).
We summary that pre-menopausal women with controlled HIV and no other CVD risk factors developed defective microvascular EDRF/NO related to reduced NOS substrate: inhibitor ratio accompanied by a new EDCF related to ROS that was accompanied by inflammation.
2. The Acetylcholine induced relaxation pathway, we found that acetylcholine induced relaxation in microvessels from in African women depends not only on EDRF/ NO and endothelium-derived hyperpolarizing factor (EDHF), but also depends on prostacyclin (PGI2, block by indomethacine) and hydrogen sulfide (block by β-cyanoalanine), which is novel (Fig. 3). According to these new findings, Dr. Dan Wang received an NIH supplemental administrative Award from DC-CFAR ? ?Microvascular endothelial function and aging in patients with HIV/AIDS? and will continue to use subjects identified from the local WIHS site.
3.. We have conducted mRNA arrays on perivascular adipose tissue (PVAT) from four women of HIV/AIDS and 4 of controls . The micro RNA pathway points remarkably to differences in leptin (LEP) signaling. This result suggest that Leptin could be the basis for the abnormal PVAT regulation of microvessel function in pre-menopausal women with HIV/AIDS (Fig. 4). mRNA arrays on the vessels themselves are waiting for mesurement If the differentiated expression of Leptin can be confirmed in the full study, we will test the role of leptin first in the rat MRA/model. If it can again be confirmed, we will test its role in the human subdermal microvessels.
|
| Jobs Created |
0.00 |
| Description of Jobs Created |
None
|
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0900 |
| Award Information |
| Award Date |
06/14/2010 |
| Award Number |
3U01AI034994-17S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$1,223,446 |
| Funds Invoiced/Received |
$1,116,352 |
| Expenditure Amount |
$1,116,352 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
U01 - NTEE |
| Activity Description |
Alliances & Advocacy |
| Sub-Awards Information |
| Sub-awards to Organizations |
1 |
| Sub-award Amounts to Organizations |
$37,625 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$31,342 |
| Number of payments to vendors less than $25,000/award |
152 |
| Total Amount of payments to vendors less than $25,000/award |
$158,442 |
Sub-award RX4335029-UL - UNIVERSITY OF LOUISVILLE
| Sub-Award Amount |
$37,625 |
| Sub-Award Date |
03/16/2012 |
| Sub-Awards Disbursed |
$32,090.55 |
| Project Location - City |
Louisville |
| Project Location - State |
KY |
| Project Location - Zip Code |
40292-0001 |
| Project Location - Congressional District |
03 |
| Sub-Recipient DUNS Number |
057588857
|
| Sub-Recipient Address |
2301 S 3RD ST |
| Sub-Recipient City |
LOUISVILLE |
| Sub-Recipient State |
Kentucky |
| Sub-Recipient Zip Code |
40208-1838 |
| Sub-Recipient Congressional District |
03 |
Required To Report Top 5
Highly Compensated Officials |
No |
DMT-USA, INC. - Award Number 3U01AI034994-17S1 - DMT-USA, INC.
| Award Number |
3U01AI034994-17S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
30303-1735 |
| Vendor Name |
DMT-USA, INC. |
| Product and Service Description |
Multi Myograph Chamber |
| Payment Amount |
$31,342 |
| Location Information |
| Latitude, Longitude |
38º 54' 27",
-77º 4' 17" |
| Congressional District |
01 |
| Address 1 |
37th & O Street NW |
| Address 2 |
|
| City |
Washington |
| County |
District of Columbia |
| State |
DC |
| Zip |
20057-1789 |
|
|