UNIVERSITY OF CALIFORNIA, IRVINE
The use of nicotine via cigarette smoking forms lifelong memories that are recalled in response to environmental cues associated with previous nicotine use. This recall increases nicotine craving and is a factor for the continued use of nicotine. Memory formation requires long-lasting changes at synapses. This project will investigate how nicotine causes long-lasting changes at synapses in the hippocampus, a brain region associated with memory formation. This will help understand how the long-lasting memories are formed, which
may aid in developing therapies for preventing the relapse, and thereby promote smoking cessation.