NEW YORK UNIVERSITY
The overall goal of the proposed work in this application is to identify the biochemical mechanisms responsible for initiating protein synthesis during synaptic plasticity and memory, and whether these mechanisms are altered and can be reversed in mouse models of fragile x syndrome (FXS) and tuberous sclerosis complex (TSC). It is estimated that 1 in 150 children in the United States are born with autism spectrum disorders (ASDs). The prevalence of ASD and FXS has been estimated to be 15-30% and conversely up to 5% of children with ASDs have been found to have FXS. TSC also has a high prevalence of ASDs, estimated at 25-60%. We have proposed experiments to determine the specific mechanisms that regulate protein synthesis during multiple forms of hippocampal synaptic plasticity in normal mice, and will use pharmacological and genetic approaches to reverse alterations in synaptic plasticity in mice that model FXS and TSC. These studies have the potential to identify several new therapeutic targets for the treatment of FXS and TSC, and by extension, ASDs.
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| AWARD OVERVIEW |
| Award Number |
2R01NS047384-06 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$747,958 |
Project Location - City |
New York |
| Award Date |
07/20/2009 |
Project Location - State |
NY |
| Project Status |
Completed |
Project Location - Zip |
10012-1019
|
| Jobs Reported |
0.00 |
Congressional District |
08 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
NEW YORK UNIVERSITY |
| Recipient DUNS Number |
041968306
|
| Recipient Address |
70 WASHINGTON SQUARE S |
| Recipient City |
NEW YORK |
| Recipient State |
New York |
| Recipient Zip |
10012-1019 |
| Recipient Congressional District |
08 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Translation Regulation in Hippocampal LTP and LTD |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Universities |
| Quarterly Activities/Project Description |
As defined in the award description field, the overall goal of the proposed work in this application is to identify the biochemical mechanisms responsible for initiating protein synthesis during synaptic plasticity and memory, and whether these mechanisms are altered and can be reversed in mouse models of fragile x syndrome (FXS) and tuberous sclerosis complex (TSC). It is estimated that 1 in 150 children in the United States are born with autism spectrum disorders (ASDs). The prevalence of ASD and FXS has been estimated to be 15-30% and conversely up to 5% of children with ASDs have been found to have FXS. TSC also has a high prevalence of ASDs, estimated at 25-60%. We have proposed experiments to determine the specific mechanisms that regulate protein synthesis during multiple forms of hippocampal synaptic plasticity in normal mice, and will use pharmacological and genetic approaches to reverse alterations in synaptic plasticity in mice that model FXS and TSC. These studies have the potential to identify several new therapeutic targets for the treatment of FXS and TSC, and by extension, ASDs. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
No jobs were created/retained with Recovery Act funding in this quarter. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0901 |
| Award Information |
| Award Date |
07/20/2009 |
| Award Number |
2R01NS047384-06 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$747,958 |
| Funds Invoiced/Received |
$747,958 |
| Expenditure Amount |
$747,958 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
B43 - NTEE |
| Activity Description |
Universities |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
218 |
| Total Amount of payments to vendors less than $25,000/award |
$171,564 |
| Location Information |
| Latitude, Longitude |
40º 43' 33",
-73º 59' 54" |
| Congressional District |
08 |
| Address 1 |
|
| Address 2 |
|
| City |
New York |
| County |
New York |
| State |
NY |
| Zip |
10012-1019 |
|
|