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Grants - AWARD SUMMARY


GEORGETOWN UNIVERSITY (THE)


Aging and aging associated diseases are likely to impart staggering health care costs upon the nation. Hence, there is a critical need to better understand biological aging through the characterization of the molecular changes associated with the aging process, so that potential targets for prevention and therapeutics can be more thoroughly explored. Since chronological age is the best predictor of biological age and age-related diseases, this initiative seeks to profile the metabolic differences between young and old populations of wild type C57BL/6 mice and subsequently study the impact of select stressors on the study population. In addition, since p38 signaling plays a major role in enhancing the expression of some senescence-related genes, stress responses will be investigated in p38a-mutant young and old mice. These mouse models will be used to establish a foundation for future research with human samples and subjects. This proposal is an extension of an ongoing project titled "Genomic and metabolomic responses to alcohol-induced liver damage" (5U01ES016013-02) and as such aims to broaden the scope of the original study. This project combines the unique expertise and experience of Frank J. Gonzalez's laboratory (National Cancer Institute) and Albert J. Fornace's laboratory. This competitive supplement will support studies on the effects of aging on injury responses by alcohol as well as select environmental toxicants. These studies will also contribute to the development of aging-associated biomarkers and the elucidation at the metabolomic level of changes occurring during stress-induced cellular senescence and biological aging. PUBLIC HEALTH RELEVANCE: The objective of the parent grant is to define effects of chronic alcohol consumption on the liver's genomic and metabolic programs, aiming to exploit these "omic" alterations for use as biomarkers and potential therapeutic intervention of alcohol-induced liver disease. We expand the work scope for insight into metabolic changes, underscoring biological aging processes and correlating effects of environmental and lifestyle metabolomic changes, underscoring biological aging processes and correlating effects of environmental and lifestyle stressors (alcohol) with aging. This contributes to a systems understanding of aging though metabolomics

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AWARD OVERVIEW

AWARD OVERVIEW
Award Number 3U01ES016013-03S1 Funding Agency Department of Health and Human Services
Total Award Amount $230,250 Project Location - City Washington
Award Date 06/04/2010 Project Location - State DC
Project Status Completed Project Location - Zip 20057-1789
Jobs Reported 0.00 Congressional District 98
Project Location - Country US

Recipient Information (Grants)

Recipient Information (Grants)
Recipient Name GEORGETOWN UNIVERSITY (THE)
Recipient DUNS Number 049515844
Recipient Address 37TH & O STS NW
Recipient City WASHINGTON
Recipient State District of Columbia
Recipient Zip 20057-0001
Recipient Congressional District 98
Recipient Country USA
Required to Report Top 5
Highly Compensated Officials		 No

Projects and Jobs Information

Projects and Jobs Information
Project Title GENOMIC AND METABOLOMIC RESPONSE TO ALCOHOL-INDUCED LIVER DAMAGE
Project Status Completed
Final Project Report Submitted Yes
Project Activities Description Biological & Life Sciences
Quarterly Activities/Project Description In this competitive supplement, we have investigated the correlation of aging and metabolism after alcohol as well as ionizing radiation as environmental toxicants using a mouse models approach to provide reasonably well-defined types of damage and damage-response pathways to compare. Important stress/injury responses are known to change with age, and stress, such as oxidative damage, probably contributes to cellular aging. In addition, my laboratory and our collaborators have found that p38 MAP kinase-mediated stress responses have important roles in cellular senescence and recently in aging-related growth suppression responses, which probably represent aging-associated senescence in vivo. During the course of this work, we have successfully determined a metabolomics signature of aging, and are processing results for the effect of aging on stress signaling. This, we believe is the first step in developing approaches to assess biological aging and metabolic events contributing to aging-related disability. Our future efforts will be directed towards evaluating tissue specific metabolic changes in response to aging and environmental toxicants.
Jobs Created 0.00
Description of Jobs Created none


Purchaser Information (Grants)

Purchaser Information
Contracting Office ID Not Reported
Contracting Office Name Not Available
Contracting Office Region Not Available
TAS Major Program 75-0863

Award Information

Award Information
Award Date 06/04/2010
Award Number 3U01ES016013-03S1
Order Number
Award Type Grants
Funding Agency ID 75
Funding Agency Name Department of Health and Human Services
Funding Office Name Not Available
Awarding Agency ID 75
Awarding Agency Name Department of Health and Human Services
Amount of Award $230,250
Funds Invoiced/Received $230,250
Expenditure Amount $230,250
Infrastructure Expenditure Amount $0
Infrastructure Purpose and Rationale Not Reported
Infrastructure Point of Contact Name Not Reported
Infrastructure Point of Contact Email Not Reported
Infrastructure Point of Contact Phone Not Reported
Infrastructure Point of Contact Address Not Reported
Infrastructure Point of Contact City Not Reported
Infrastructure Point of Contact State Not Reported
Infrastructure Point of Contact Zip Not Reported

Product or Service Information (Grants)

Product or Service Information
Primary Activity Code U50 - NTEE
Activity Description Biological & Life Sciences

Sub-Awards Information

Sub-Awards Information
Sub-awards to Organizations 0
Sub-award Amounts to Organizations $0
Sub-Awards to Individuals 0
Sub-Award Amounts to Individuals $0
Number of Sub-awards less than $25,000/award 0
Amount of Sub-awards less than $25,000/award $0
Number of payments to vendors greater than $25,000 0
Total Amount of payments to vendors greater than $25,000/award $0
Number of payments to vendors less than $25,000/award 0
Total Amount of payments to vendors less than $25,000/award $0







Project Location Detail

Location Information
Latitude, Longitude 38º 54' 27", -77º 4' 17"
Congressional District 98
Address 1 37th & O Street NW
Address 2
City Washington
County District of Columbia
State DC
Zip 20057-1789
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