NEW YORK UNIVERSITY
This supplement provides support to retain a project technician. This work has far reaching implications in the physiology and pathophysiology of skeletal tissues. Alterations in chondrocyte maturation and hypertrophy have catastrophic physiologic and quality of life outcomes, exemplified by severe chondrodystrophy and dwarfism. Understanding the regulation of chondrocyte maturation has important potential for developing interventional therapies in growth anomalies. Chondrocytes also play crucial roles in fracture repair and distraction osteogenesis. Moreover, understanding the basic signaling mechanisms in endochondral bone formation provides information vital to tissue engineering of bone replacement materials, important for correction of deformities like cleft palates or for reconstructive surgery after tumor removal.
The project is completed, and the remaining balance of $1,438.41 will not be claimed.