OREGON HEALTH & SCIENCE UNIVERSITY
Nonhuman primate (NHP) models area essential to the conduct of translational research and the advancement of biomedical science. There is a critical need to increase the NHP housing and research capacity to address major human health threats. The Oregon National Primate Research Center (ONPRC) is completing construction of the new Animal Service and Animal Biosafety Level 3 (ASA) building in Jul 2009. The purpose of this proposal is to provide the staff needed for animal care and research support in the new ASA building. The new building will provide animal housing and support space for two major research programs: the Metabolic Disease Working Group and the Bioterrorism and Emerging Pathogens programs. The focus of the metabolic Disease Working Group is to develop and use NHP models of diet-induced obesity to study associated diseases. Obesity is a worldwide health epidemic, being a major contributor to the increased occurrence of coronary heart disease, hypertension, immune disorders and type-2 diabetes. Sixty to ninety percent of type-2 diabetes (the most common form of diabetes, previously called adult-onset diabetes) is thought to result from obesity. Obesity and the metabolic syndrome are also now implicated in increased risk for a range of cancers. The Bioterrorism and Emerging Pathogens program seeks to understand the disease caused by emerging infectious pathogens and to develop vaccines to protect vulnerable populations. The program is designed to rapidly respond to national priorities such as influenza H1N1. The threat of bioterrorism and the increased realization of the dangers associated with emerging infectious disease create a critical need for research infrastructure that can support BSL 3/ABSL 3 projects. The new ASA building meets a national need for specialized research capacity and requires a competent veterinary, husbandry and biosafety staff.