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Grants - AWARD SUMMARY


CHILDREN'S HOSPITAL CORPORATION, THE


We will investigate whether IgE levels regulate mast cell numbers in the intestine during a response to food allergens. This work has been completed by Natalia Diaz who was hired under this award as a summer student and has now left the lab.

Clarification of Codes

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AWARD OVERVIEW

AWARD OVERVIEW
Award Number 3R01AI054471-05S1 Funding Agency Department of Health and Human Services
Total Award Amount $11,154 Project Location - City Boston
Award Date 06/04/2009 Project Location - State MA
Project Status Completed Project Location - Zip 02115-5724
Jobs Reported 0.00 Congressional District 08
Project Location - Country US

Recipient Information (Grants)

Recipient Information (Grants)
Recipient Name CHILDREN'S HOSPITAL CORPORATION, THE
Recipient DUNS Number 076593722
Recipient Address 300 LONGWOOD AVE
Recipient City BOSTON
Recipient State Massachusetts
Recipient Zip 02115-5724
Recipient Congressional District 08
Recipient Country USA
Required to Report Top 5
Highly Compensated Officials		 No

Projects and Jobs Information

Projects and Jobs Information
Project Title Regulation of Immune Responses by IgE and Mast Cells
Project Status Completed
Final Project Report Submitted Yes
Project Activities Description Hospitals
Quarterly Activities/Project Description The summer student contributed to the initial characterization of a novel model of food allergy in mice. In most existing murine models, enteral sensitization alone does not give rise to anaphylactic responses upon enteral challenge. Through collaboration with Dr. Talal Chatila (UCLA), we have recently obtained animals harboring activating mutations of the IL-4 receptor ?-chain. These mice seem uniquely susceptible to immune sensitization by enteral antigens. During her two months in the lab, Ms. Diaz helped move the characterization of food allergen responses in these animals by along by participating in the allergen sensitization of the mice, measurement of physiologic responses and analysis of cytokine responses in the gut by quantitative real-time PCR. Her experiments contributed to our findings that IL-4R? mutants, but not wild-type controls, exhibit symptoms of anaphylaxis, drops in core temperature and robust IgE responses (Figure 1) after enteral sensitization. In relation to the parent grant, she participated in mast cell enumerations and measurement of both total and specific IgE responses in the OVA-fed animals.
Jobs Created 0.00
Description of Jobs Created Children’s Hospital Boston is the only hospital in Massachusetts committed entirely to the health care of children and offers a comprehensive range of health care services and pioneering knowledge and therapies in accordance with its research mission. CHB is also dedicated to being a caring and responsive community partner and leader in civic and public policy. Children's Hospital Boston is a major employer and provider of services for the city, state and greater New England region. A recent study on the social and economic impact of CHB on the local level, indicates that the operations of CHB generated $533 million in economic activity and more than $27.7 million in revenue for the City of Boston in 2006. In 2008 CHB provided direct employment for 8,832 residents of the region. This number represents an 8% growth from 2007 in direct employee numbers and reflects the upward trend we would like to continue. Opportunities from the federal stimulus funding will assist in this goal. For this reporting period no jobs were created or retained.


Purchaser Information (Grants)

Purchaser Information
Contracting Office ID Not Reported
Contracting Office Name Not Available
Contracting Office Region Not Available
TAS Major Program 75-0900

Award Information

Award Information
Award Date 06/04/2009
Award Number 3R01AI054471-05S1
Order Number
Award Type Grants
Funding Agency ID 75
Funding Agency Name Department of Health and Human Services
Funding Office Name Not Available
Awarding Agency ID 75
Awarding Agency Name Department of Health and Human Services
Amount of Award $11,154
Funds Invoiced/Received $6,808
Expenditure Amount $6,808
Infrastructure Expenditure Amount $0
Infrastructure Purpose and Rationale Not Reported
Infrastructure Point of Contact Name Not Reported
Infrastructure Point of Contact Email Not Reported
Infrastructure Point of Contact Phone Not Reported
Infrastructure Point of Contact Address Not Reported
Infrastructure Point of Contact City Not Reported
Infrastructure Point of Contact State Not Reported
Infrastructure Point of Contact Zip Not Reported

Product or Service Information (Grants)

Product or Service Information
Primary Activity Code E20 - NTEE
Activity Description Hospitals

Sub-Awards Information

Sub-Awards Information
Sub-awards to Organizations 0
Sub-award Amounts to Organizations $0
Sub-Awards to Individuals 0
Sub-Award Amounts to Individuals $0
Number of Sub-awards less than $25,000/award 0
Amount of Sub-awards less than $25,000/award $0
Number of payments to vendors greater than $25,000 0
Total Amount of payments to vendors greater than $25,000/award $0
Number of payments to vendors less than $25,000/award 1
Total Amount of payments to vendors less than $25,000/award $773







Project Location Detail

Location Information
Latitude, Longitude 42º 20' 14", -71º 6' 15"
Congressional District 08
Address 1
Address 2
City Boston
County Suffolk
State MA
Zip 02115-5724
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