PENNSYLVANIA STATE UNIVERSITY, THE
The increasing burden of malaria, in part, due to drug resistance in the parasite Plasmodium falciparum,demands new therapies. Recent research in the field of transcription has demonstrated the functionalimportance of chromatin in regulating gene expression in eukaryotes. Enzymes that modulate chromatinstructures have a profound effect on controlling gene expression. Among these enzymes, histoneacetyltransferases (HATs), which transfer the acetyl group from acetyl-CoA to the lysine residues in the N-terminal tails of histones, are the best studied. The antiparasitic effects of drugs that disturb histoneacetylation and recent studies from our group on the chromatin remodeling factors in P.falciparumdemonstrated that dynamic histone acetylation is an important epigenetic mechanism of transcriptionregulation and plays a prominent role in development of the malaria parasite.