REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE
We will accelerate the goals of the parent grant while retaining 3 existing staff and hiring 2 new staff. This application allows the Berkeley GDAC to match the productive power of the rest of the TCGA project which has been massively accelerated with ARRA funding. Specifically, we will focus on getting the histopathological and RNAseq pipelines in place to handle multiple tumor types and distinct types of analyses. The key improvements in this application are quantifying necrosis, apoptosis, hemorrhage, and normal cells in each tissue image. We will accomplish this task through multiscale analysis of images that is coupled with pathologist-defined training.