JOHNS HOPKINS UNIVERSITY, THE
Lung involvement is currently the leading cause of morbidity and mortality in scleroderma (SSc) patients. Interstitial lung disease (ILD) is the most common pulmonary manifestation and may result from an abnormal immune response carried out by pro-fibrotic effector T cells. In this study, entitled ?T cell response in scleroderma lung disease: from pathogenesis to clinical care?, we will prospectively study the features and the magnitude of the immune response, and in particular of the pro-fibrotic T cell subsets, in SSc patients before and during the progression to pulmonary fibrosis.
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| AWARD OVERVIEW |
| Award Number |
3K23AR055667-02S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$100,000 |
Project Location - City |
Baltimore |
| Award Date |
09/18/2009 |
Project Location - State |
MD |
| Project Status |
Completed |
Project Location - Zip |
21218-2680
|
| Jobs Reported |
0.00 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
JOHNS HOPKINS UNIVERSITY, THE |
| Recipient DUNS Number |
001910777
|
| Recipient Address |
3400 N CHARLES ST W400 WYMAN PARK BLDG |
| Recipient City |
BALTIMORE |
| Recipient State |
Maryland |
| Recipient Zip |
21218-2680 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
T CELL RESPONSE IN SCLERODERMA LUNG DISEASE: FROM PATHOGENESIS TO CLINICAL CARE |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Colleges, Universities, and Professional Schools |
| Quarterly Activities/Project Description |
The FFR was signed on 10/24/11. The primary objective of this administrative supplement was to provide support for a full time research technician assisting the principal investigator (Dr. Boin) in the organization and conduction of the experimental portion of the parent grant (K23 AR055667). The new position has been crucial in order to start enrolling patients immediately from the beginning of the supported period. His contribution has been essential to maintain a steady patient recruitment rate and to organize on a daily base the storage of samples and the filing of generated data. The technician has gained independence in term of acquiring data with the flow cytometer, and became involved in the analysis of available data using FlowJo, a cutting edge flow cytometry analysis software. During the last quarter of this grant, the project has been progressing swiftly. At this time we have enrolled 140 patients in visit #1, 100 in visit #2, 60 in visit #3, 40 visit #4 and we are starting now with visit #5 (interval between visits is 6 months). The collection of data as well as the organization of stored samples collected at each visit is ongoing. We generated a bank of different specimens such as DNA/RNA extracted from peripheral blood mononuclear cells (PBMCs), the supernatant from stimulated PBMC for cytokine secretion profiling, the serum and plasma for each patient, at each visit, which will be used for nested studies. The research technician supported through this ARRA funding will remain the crucial quarterback of all the streamlined procedures for sample collection, analysis and storage even after the grant has expired. This project has ended and all funds were fully exhausted. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
No jobs were created or retained. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0903 |
| Award Information |
| Award Date |
09/18/2009 |
| Award Number |
3K23AR055667-02S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$100,000 |
| Funds Invoiced/Received |
$100,000 |
| Expenditure Amount |
$100,000 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
611310 |
| Activity Description |
Colleges, Universities, and Professional Schools |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
25 |
| Total Amount of payments to vendors less than $25,000/award |
$8,905 |
| Location Information |
| Latitude, Longitude |
39º 19' 50",
-76º 37' 5" |
| Congressional District |
07 |
| Address 1 |
3400 N. Charles Street |
| Address 2 |
|
| City |
Baltimore |
| County |
Baltimore City |
| State |
MD |
| Zip |
21218-2680 |
|
|