UNIVERSITY OF FLORIDA
Proteomics is one of emerging tools for drug discovery and medical diagnostics. Two-dimensional gel electrophoresis is one of the most potent methods in proteomics studies. The goal of this project is to develop a lab-on-a-chip device that will improve the performance of conventional gel electrophoresis. Two separation mechanisms will be integrated with microvalves and other components in the device. The impacts of the research could be significant because gel electrophoresis is widely used in biological laboratories. After the platform is successfully implemented, it could be used for studying the association between biomarkers and diseases including those related to traumatic brain injury. After the biomarkers are established and clinically validated, the platform could also become a rapid, quantifiable diagnostic tool to help physicians determine the seriousness of the diseases based on the level of the biomarkers present in the patients? bodily fluids.