UNIVERSITY OF ARIZONA
Project Narrative CD46 is a protein that regulates many immune functions in man. CD46 comes in two main forms, and there is reason to believe that the result of CD46 stimulation depends on the relative levels of the two activated forms. CD46 is also the target for many viruses and bacteria - herpesvirus6, adenovirus, Group A Streptococci, Neisseria meningitidis and Neisseria gonorrhoeae. Our goal here is to understand how Neisseria regulates the activity of CD46 through the Presenilin/?-Secretase protease. Our hope is that this knowledge will be useful for developing methods to control microbial infections.