CHILDREN'S HOSPITAL CORPORATION, THE
Epilepsy affects over 1% of the US population, and up to 30% of people suffering from epilepsy do not respond to conventional antiepileptic drugs (AEDs). The newly FDA-approved AED vigabatrin has improved efficacy in this population yet its use has been limited by a 30% incidence of severe irreversible retinal and brain toxicity. The present proposal addresses the mechanism of this toxicity and proposes to attenuate this with a novel agent bumetanide, which has a good safety profile in humans in its use for unrelated indications. No current treatment for the irreversible side effects of vigabatrin exists, and successful demonstration of efficacy of bumetanide in animal models of vigabatrin toxicity proposed here will facilitate clinical trials in patients receiving vigabatrin for refractory epilepsy.
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| AWARD OVERVIEW |
| Award Number |
1RC1NS068938-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$813,511 |
Project Location - City |
Boston |
| Award Date |
09/25/2009 |
Project Location - State |
MA |
| Project Status |
Completed |
Project Location - Zip |
02115-5724
|
| Jobs Reported |
0.03 |
Congressional District |
08 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
CHILDREN'S HOSPITAL CORPORATION, THE |
| Recipient DUNS Number |
076593722
|
| Recipient Address |
300 LONGWOOD AVE |
| Recipient City |
BOSTON |
| Recipient State |
Massachusetts |
| Recipient Zip |
02115-5724 |
| Recipient Congressional District |
08 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibitor |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Hospitals |
| Quarterly Activities/Project Description |
We have completed the last group of animals and are currently processing them for evaluation of the therapeutic effect; the project is 90% complete and we are on schedule to complete this project at the end of August 2012. |
| Jobs Created |
0.03 |
| Description of Jobs Created |
Children’s Hospital Boston is the only hospital in Massachusetts committed entirely to the health care of children and offers a comprehensive range of health care services and pioneering knowledge and therapies in accordance with its research mission. CHB is also dedicated to being a caring and responsive community partner and leader in civic and public policy.
Children's Hospital Boston is a major employer and provider of services for the city, state and greater New England region. A recent study on the social and economic impact of CHB on the local level, indicates that the operations of CHB generated $533 million in economic activity and more than $27.7 million in revenue for the City of Boston in 2006. In 2008 CHB provided direct employment for 8,832 residents of the region. This number represents an 8% growth from 2007 in direct employee numbers and reflects the upward trend we would like to continue. Opportunities from the federal stimulus funding will assist in this goal. For this reporting period 0.03 jobs were created or retained (Principal Investigator) August job data not previously reported. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0901 |
| Award Information |
| Award Date |
09/25/2009 |
| Award Number |
1RC1NS068938-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$813,511 |
| Funds Invoiced/Received |
$813,511 |
| Expenditure Amount |
$813,511 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
E20 - NTEE |
| Activity Description |
Hospitals |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
260 |
| Total Amount of payments to vendors less than $25,000/award |
$96,649 |
| Location Information |
| Latitude, Longitude |
42º 20' 14",
-71º 6' 15" |
| Congressional District |
08 |
| Address 1 |
|
| Address 2 |
|
| City |
Boston |
| County |
Suffolk |
| State |
MA |
| Zip |
02115-5724 |
|
|