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TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

This administrative supplement provides an opportunity for Dr. Manjunath Harlapur, a post-doctoral fellow, to receive high quality training in conducting patient-oriented translational research in the area of preventive cardiology. Dr. Harlapur?s research interest is in the translational sciences specifically in the area of cardiovascular disease (CVD) biomarkers. The primary aims of the proposed research are for Dr. Harlapur: (1) to be trained in epidemiologic research, (2) to acquire experience in the analysis of longitudinal data, (3) to be trained in relevant laboratory techniques applicable to conducting translational research, (4) to obtain research training in preventive cardiology, and (5) to refine his ability to articulate research ideas and disseminate findings. The proposed administrative supplement will allow Dr. Harlapur to obtain this research training within the context of the parent study (R01HL091099). The primary aims of the parent study are to determine the independent contributions of depression and cellular aging to the risk for incident CVD events. To accomplish these aims, leukocyte TL will be assayed in a population-based, prospective sample (1995 Nova Scotia Health Study, NSHS95) of 987 persons with documented absence of CVD, but with baseline assessment of traditional risk factors including depression status, and full capture of 10-year incident CVD events including mortality. The parent study offers an outstanding opportunity for Dr. Harlapur?s research training and for the aims of the administrative supplement to be met.

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