CALIFORNIA INSTITUTE OF TECHNOLOGY
1. The holographic recording material proposed on the parent grant proves to be too insensitive for practical application. We plan to explore a range of other holographic materials including near infrared (NIR) sensitive materials (InPhase Technologies, Bayer Material Science) which allows a faster and simpler reflection mode TSOPC measurement and extends the working range of TSOPC to NIR. To further enhance the focusing onto the strong scatterers embedded in tissues, we propose to perform itera
tive reflection mode TSOPC measurement. Elastic scattering in thick tissues reduces the scattering contrast of the embedded scatterers. Iterative measurement can enhance the scattering contrast and efficiently focus light onto the strongest scatterers. 2. One way to monitor the enhanced focusing in reflection mode TSOPC is to detect the Raman signal from the target, which may find applications in using Raman spectroscopy to analyze the inhomogeneity in tissues. We plan to implement a detection
system which is capable of monitoring both Raman scattering and fluorescence signals from the targets. 3. To date we have been able to perform high fidelity TSOPC measurement through 1 cm thick chicken tissues. The current experiment is limited by the sensitivity and the dark noise of the low profile CCD camera. We will implement an interferometric detection system to better address the penetration depth limit experiment. 4. The current TSOPC experiment has several properties in common with th
e universal transmission experiment demonstrated in 2008 by Professor Allard Mosk s team. Past communications with Mosk s team have been beneficial for understanding various aspects of TSOPC. We would like to invite the key researcher Ivo Vellokoop to work with us for three months per year (six months in total) and develop a better theoretical understanding of TSOPC.