NEMOURS FOUNDATION, THE
The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of Delaware. This will be accomplished through the efforts of a multidisciplinary group of investigators at the Nemours Research Institute/Alfred I. duPont Hospital for Children, to study pediatric diseases, therapy and prevention. The Nemours Research Institute is located on the grounds of the Alfred I. duPont Hospital in Wilmington, Delaware, where a close relationship is maintained between the two facilities. The new research center, The Center for Pediatric Research (CPR), will focus on three aims: 1) To develop a Center that will support basic and applied research on pediatric disorders by providing the infrastructure to train basic and physician scientists (target investigators) in their quest to become independent investigators who can successfully procure outside funding for their research programs. The CPR will foster the development of these junior scientists by providing the money, resources and core lab services for the projects; 2) To develop an integrated mentoring program to enrich the training of the target investigators. Established investigators with proven histories in scientific research and grant acquisition will provide scientific and academic direction to the target investigators, thus fostering the advancement of this core group of scientists to build a stronger research program, ensuring the long-term expansion of biomedical research in Delaware; and 3) To develop a translational research program within the CPR that enriches the interface between clinical and basic research by developing clinically relevant systems for basic research as well as scientifically sound approaches to clinical research. We will recruit investigators with experience in clinical and applied basic research to form a multidisciplinary research group studying pediatric diseases, providing additional research programs and infrastructure for the long-term development of an NIH-funded Translational CPR at the Nemours Research Institute. The COBRE program proposed herein will have two long-term benefits: 1) the number of NIH-competitive researchers in Delaware will increase; 2) the CPR will be poised to apply for a other Center grants which are few in Delaware.
| AWARD OVERVIEW |
| Award Number |
3P20RR020173-05S3 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$197,625 |
Project Location - City |
Wilmington |
| Award Date |
09/28/2009 |
Project Location - State |
DE |
| Project Status |
Completed |
Project Location - Zip |
19803-3607
|
| Jobs Reported |
0.00 |
Congressional District |
00 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
NEMOURS FOUNDATION, THE |
| Recipient DUNS Number |
038004941
|
| Recipient Address |
1600 ROCKLAND |
| Recipient City |
WILMINGTON |
| Recipient State |
Delaware |
| Recipient Zip |
19803-3607 |
| Recipient Congressional District |
00 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
CENTER FOR PEDIATRIC RESEARCH |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research |
| Quarterly Activities/Project Description |
The research on the grant was completed by the end of September 2011. Quarterly activities are as defined in the Award Description field. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
For the first fifteen months of this grant the following five jobs were created: 2 Research Scientists positions (1 person at .05 FTE and 1 person at .2 FTE) and
3 Research Technicians (2 person at 1.0 FTE and one at .12 FTE). Of these, two of these positions have transitioned to a funded competing continuation of this grant. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0847 |
| Award Information |
| Award Date |
09/28/2009 |
| Award Number |
3P20RR020173-05S3 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$197,625 |
| Funds Invoiced/Received |
$197,625 |
| Expenditure Amount |
$197,625 |
| Infrastructure Expenditure Amount |
$197,625 |
| Infrastructure Purpose and Rationale |
The third specific aim of our NCRR funded COBRE award, the Center for Pediatric Research (P20 RR020173), focuses on increasing the success of our Nemours' investigators in competing for NIH-funding. To better accomplish this, we received supplemental funds through the NCRR ARRA Administrative Supplements for Enhancing NCRR Pilot Project Mechanism (start date 9/30/09). We proposed two pilot projects below. The objectives of each project address the overarching goal of the Center for Pediatric Research (CPR), to increase translational research programs within our institute. Moreover, these specific projects enhance the Center through new innovative studies that have not previously been funded through this COBRE mechanism. The first project, which focuses on the most common pediatric rheumatologic disease, is a new research project led by a promising and energetic junior clinician scientist (Brescia). This project will also serve to promote and enhance interactions between clinicians and basic scientists, since the pilot investigator will be co-mentored both by a practicing senior pediatric rheumatologist (Rose) and a senior clinician investigator who maintains an NIH funded basic research program (Schanen). The second pilot project, which focuses on testing a potential treatment strategy for human mutations leading to altered RNA splicing, is a new project led by a recently R01 funded investigator from our Center program (Hobson). This project will provide proof-of-principle data to serve as the basis for full-scale investigation as well as bring new research methodologies and technologies to the CPR. Both pilot projects will further promote interdisciplinary, translational research within the CPR. These investigators provide a bridge between the first phase of the COBRE program that was designed to create the CPR and the second phase of the COBRE that is designed to take advantage of the achievements of this center by training more investigators.
1. The projects also promote economic growth through the purchase of reagents and supplies from US vendors that require shipping and use of core laboratory staff, which also preserves job positions.
2. Many of the candidates we have interviewed have been directly impacted by the recession including individuals who have either lost their jobs or are unable to find positions because of the poor economy. Thus, hiring these two positions was helpful and the coincident increase in purchasing of supplies and reagents is also stimulating to the economy.
3. Both projects are technology based and promote the development of innovative approaches to diagnosis, management and potential treatment of childhood disorders. These may improve and streamline management, ultimately decreasing the burden of cost for caring for children with these disorders that have life-long risks of disabilities.
4. The purchase of reagents and supplies from largely US based vendors by the scientific community supports the transportation system in the US.
5. Improving the rate of unemployment decreases the burden of costs for services on the state. Since DE is a small state, we actually affect our neighboring states (PA, MD, NJ) by employing individuals from those states. Ultimately, this helps decrease the governmental costs for state and local government to support the regional populations. |
| Infrastructure Point of Contact Name |
Vicky L. Funanage, PhD |
| Infrastructure Point of Contact Email |
vfunanag@nemours.org |
| Infrastructure Point of Contact Phone |
(302) 651-6819 |
| Infrastructure Point of Contact Address |
1600 Rockland Road |
| Infrastructure Point of Contact City |
Wilmington |
| Infrastructure Point of Contact State |
DE |
| Infrastructure Point of Contact Zip |
19803-3607 |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H - NTEE |
| Activity Description |
Medical Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
22 |
| Total Amount of payments to vendors less than $25,000/award |
$48,965 |
| Location Information |
| Latitude, Longitude |
39º 46' 53",
-75º 33' 14" |
| Congressional District |
00 |
| Address 1 |
1600 Rockland Road |
| Address 2 |
Rockland Center 1 |
| City |
Wilmington |
| County |
New Castle |
| State |
DE |
| Zip |
19803-3607 |
|
|