UNIVERSITY OF ROCHESTER
The project comprises 3 enhancements to an existing Center of Research Translation grant, entitled "Translating molecular signal pathways to orthopaedic trauma care". The first provides salary support for personnel and animal/supply support to conduct experiments on a new therapeutic agent for protection or regeneration of articular cartilage in osteoarthritis, using mouse models. The second provides technical support for experiments to study the role of stem cells from periosteum in impairment of fracture healing associated with aging. The third allows construction of a portable device to measure function after lower extremity fractures to enhance accrual in a randomized clinical trial of parathyroid hormone treatment for pelvic insufficiency fractures.