UNIVERSITY OF ILLINOIS
"Role of p67 phox in myocardial hypertrophy" This ARRA project will provide crucial data directly contributing to validation of the central hypothesis of our parent R01 grant. These supplemental experiments will directly test our working hypothesis that the protein interaction domain PB1 of p67phox is involved in alpha-1-adrenergic receptor (A1-AR)-stimulated cardiac hypertrophy but not in ROS generation in vitro, which is a critical and integral part of the parent R01 project, and will greatly contribute to our efforts in confirming our central hypothesis in the parent R01 grant that an ROS-independent signaling mechanism of p67phox involves in mediating cardiac hypertrophy. In addition, this supplemental funding to our current R01 grant helped us create one new full-time postdoctoral research fellow position, which enables us to hire one additional postdoctoral researcher to work in my lab immediately. This immediate new job creation and hiring of Dr. Yuhui Shi fit perfectly well with the objectives of the American Recovery and Reinvestment Act (ARRA). Furthermore, this newly created postdoctoral fellow position and the supplemental funding for lab supplies will enable us to expand our current research onto the above proposed supplemental aims that are critical for testing our hypothesis, which will significantly accelerate the tempo of our current NIH-funded research project in my lab. As we all know that the extra hands with well-trained research skills and the additional research funding for lab supplies are always a great support especially for a New Investigator?s start-up lab like mine, and thus will definitely make major positive impact on our scientific research progress, which also meets the objective of ARRA funding for promoting NIH-sponsored biomedical research.