UNIVERSITY OF WASHINGTON
We now apply for an Administrative Supplement to obtain such funding for each of 2 years, to obtain additional clinical material from Dr Swisher which is needed to evaluate mesothelin as a biomarker for immunodiagnosis and monitoring of patients with ovarian carcinoma and to explore two new leads from recent studies supported by the parent grant. We expect that an award would lead to better ways to diagnose and treat OvC and yield both short-term and long-term economic gains.
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| AWARD OVERVIEW |
| Award Number |
3R01CA134487-02S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$274,911 |
Project Location - City |
SEATTLE |
| Award Date |
08/31/2009 |
Project Location - State |
WA |
| Project Status |
Completed |
Project Location - Zip |
98195-0000
|
| Jobs Reported |
0.00 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF WASHINGTON |
| Recipient DUNS Number |
605799469
|
| Recipient Address |
4333 BROOKLYN AVE NE |
| Recipient City |
SEATTLE |
| Recipient State |
Washington |
| Recipient Zip |
98195-0001 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Mesothelin as biomarker and therapeutic target |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
1.The manuscript "Autoantibodies to mesothelin in infertility" by JL Luborsky, Y.Yu, SL Edassery, J Jaffar, YY Yip, P Liu, KE Hellstrom and I Hellstrom has been published in Cancer Epidemiol Biomarkers Prev 20 (9), 1970-1978, 2011. Epub 1011 Aug 16.2. A manuscript "Evaluation of ovarian cancer remission markers HE4, MMP7 and mesothelin by comparison to the established marker CA125" has been submitted to Gynecol. Oncology by M Schummer, C Drescher, C, R Forrest, S Gough, J Thorpe, I Hellstrom, KE Hellstrom, and NE Urban, N. E. Our conclusion is that HE4 can predict ovarian cancer recurrence earlier than CA125 and be elevated in patients that do not express CA125 at sufficient levels to make a decision. MMP7 and mesothelin have lower potential as markers for ovarian cancer recurrence to complement CA125. Elevated HE4 throughout remission could indicate poor prognosis.3. We have used the Quiagene's Expression Kit E. coli for high level expression of mesothelin in E. coli to provide a potentially better source than CHO-produced mesothelin for antibody and T cell assays. So far, we have tested a large number of control sera/plasmas to establish cut-offs and will compare E coli produced mesothelin with the COS-produced material. 4. Ascites from patients with advanced ovarian carcinoma have an abundance of immature APC. We can mature these cells by culturing with magnetic beads conjugated to Mabs to CD3 and CD28. After maturation of the APC and in the presence of the patient's tumor cells, the supernatants contain large amounts of IFNgamma and TNFalpha, and we have preliminary evidence that specific T cell responses to mesothelin can be generated. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
No Jobs Were Created or Retained. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
08/31/2009 |
| Award Number |
3R01CA134487-02S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$274,911 |
| Funds Invoiced/Received |
$274,911 |
| Expenditure Amount |
$274,911 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
8 |
| Total Amount of payments to vendors less than $25,000/award |
$11,494 |
| Location Information |
| Latitude, Longitude |
47º 39' 17",
-122º 18' 7" |
| Congressional District |
07 |
| Address 1 |
4333 Brooklyn Ave NE |
| Address 2 |
Box 359472 |
| City |
SEATTLE |
| County |
King |
| State |
WA |
| Zip |
98195-0000 |
|
|