HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M
Gastric Carcinoma is the
second leading cause of cancer
death worldwide. Because
survival at 5 year is very low,there is a need for a better understanding of the
pathogenesis of the disease.
These studies will permit a
prospective analysis of the
histological and molecular
effects of dietary components
and bacterial carcinogens
during the early and late stages of carcinogenesis in a primate model.
| AWARD OVERVIEW |
| Award Number |
2R01CA082312-09 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$672,410 |
Project Location - City |
Bethesda |
| Award Date |
06/09/2009 |
Project Location - State |
MD |
| Project Status |
Completed |
Project Location - Zip |
20814-4712
|
| Jobs Reported |
0.00 |
Congressional District |
08 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M |
| Recipient DUNS Number |
144676566
|
| Recipient Address |
1401 ROCKVILLE PIKE STE 600 |
| Recipient City |
ROCKVILLE |
| Recipient State |
Maryland |
| Recipient Zip |
20852-1402 |
| Recipient Congressional District |
08 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Bacterial and Chemical Carcinogens in Gastric Oncogenesis |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Cancer Research |
| Quarterly Activities/Project Description |
H. pylori, carcinogens, and protectant isoflavones play critical roles in gastric carcinogenesis.
Twenty-three macaques were divided into 4 groups: controls (C); oral carcinogen ethyl-nitro-nitrosoguanidine (ENNG) (E); infection with virulent H. pylori strain (H); and ENNG plus H. pylori inoculation (EH). Gastroscopies with biopsies were performed at regular intervals for 6 years.
Gastric cancer appeared in three EH macaques but not in any E, H or C animals. In addition, all E and EH macaques, but no C or H macaques, developed gastric angiodysplasia well visualized by computed virtual chromoendoscopy. The new low isoflavone diet was started and is well accepted by the animals.
We have initiated a modification of the diet of the macaques to a low isoflavone diet that enhances the carcinogenic effect of H. pylori and the carcinogen. The new IACUC protocol describing implementation of the new diet was approved. A low isoflavone diet was prepared by Harlan and a sample was tried on the macaques to habituate the animals to the new diet. Complete switch to the new diet will be done when the animals have been completely adapted to the diet.
In addition, we collaborate with Dr. Moss' group to perform Laser Capture Microdissection on archival specimens. These studies will permit to discover the genes that are overexpressed in the mucosal and submucosal regions of the stomach of animals that develop cancer in subsequent years. In turn, this discovery could lead to tests to predict cancer and to prevention of cancer.
Conclusions: H. pylori-induced inflammation plus ENNG can cause experimental gastric cancer in a non-human primate model. In the same model, ENNG exposure promotes angiogenesis and induces phenotypic changes similar to those observed in humans. The present studies will permit molecular analysis of these effects and may help in the development of new methods to predict and prevent gastric cancer.
|
| Jobs Created |
0.00 |
| Description of Jobs Created |
N/A |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
06/09/2009 |
| Award Number |
2R01CA082312-09 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$672,410 |
| Funds Invoiced/Received |
$633,180 |
| Expenditure Amount |
$633,180 |
| Infrastructure Expenditure Amount |
$633,180 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H02.04 |
| Activity Description |
Cancer Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$36,642 |
| Number of payments to vendors less than $25,000/award |
178 |
| Total Amount of payments to vendors less than $25,000/award |
$290,592 |
Micromed LLC - Award Number 2R01CA082312-09 - Micromed LLC
| Award Number |
2R01CA082312-09 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
46268-3128 |
| Vendor Name |
Micromed LLC |
| Product and Service Description |
Item #EG-590ZW, Honeycomb Video Gastroscope w/2.8mm Channel, 10.8 mm O.D., 1100mm Working Length, Warranty 6 months; Item#BF-1812SF, Biopsy Forceps, Fenestrated, 1.8mm outer diameter, 1200mm length |
| Payment Amount |
$36,642 |
| Location Information |
| Latitude, Longitude |
38º 59' 57",
-77º 5' 9" |
| Congressional District |
08 |
| Address 1 |
4301 Jones Bridge Rd |
| Address 2 |
|
| City |
Bethesda |
| County |
Montgomery |
| State |
MD |
| Zip |
20814-4712 |
|
|