TRUSTEES OF TUFTS COLLEGE INC
This award is intended to provide (1) a summer research experience for undergraduate students with an interest in pursuing a career in neuroscience, (2) an accelerated tempo of work on existing projects by employing students to carry out less specialized but vital tasks/experiments in order to allow postdoctoral reserchers time to carry out higher order specialized tasks, and (3) to aid in generating preliminary data for those projects nearing completion to increase the likelihood of submitting a successful renewal and/or new project related to the ongoing study. The parent proposal is centered around the hypothesis that astrocytes contribute to the regulation of neuronal excitability, excitotoxicity and epileptogenesis following status epilepticus. One of the student research assistants will learn to cut brain sections, to carry out antibody staining of such sections and to use immunofluorescence with confocal microscopy while the other will focus on behavioral experiments to assist with transgene expression in vivo. Both will assist senior reseachers in identifying the roles of astrocytes in the initiation and maintenance of epileptiform activity.