UNIVERSITY OF MIAMI
Continuing scientific progress in Parkinson disease (PD) and other parkinsonian syndromes relies upon accurate diagnosis of these disorders and the availability of patients and controls for study. The ongoing efforts of the current Ascertainment and Clinical Core of the Miami Udall Parkinson's Disease Research Center of Excellence include collection of an additional 200 cases and familial or spouse controls for genetic studies and the longitudinal follow-up of a cohort of 200 individuals until death and conduct post-mortem brain tissue retrieval for neuropathological and genetic studies. Any lapse in follow-up or tissue retrieval would diminish the scientific value of this resource. As well, the relocation of the Udall Center to Miami in 2007 provided a unique opportunity to expand enrollment in the study of participants of Hispanic/Latino ethnicity, an understudied group in PD. This award will help us to continue enrolling participants in the genetic study and maintain the tissue retrieval program during the pending renewal of the Miami Udall Center. The supplemental funding will allow the enrichment of the available resources, which will accelerate progress towards understanding the genetic architecture of PD. We will: 1) Continue to enroll participants (n=184) in genetic studies of PD, with emphasis on enrolling individuals of Hispanic/Latino ancestry; 2) Maintain an active autopsy and tissue donation program by following 180 currently enrolled participants, completing biennial longitudinal examinations, and continuing tissue retrievals; 3) Collect and database detailed clinical, family history, and environmental risk factor data on all participants.