UNIVERSITY OF FLORIDA
Pain is one of the most costly and pervasive public health problems threatening the United States. While ethnic disparities in pain and its treatment have been reported, the influence of ethnicity on responses to analgesics has received scant attention. In the currently funded study (NS55094), a common acute clinical pain model is used to identify and characterize psychosocial, physiological and genetic factors that contribute to ethnic group differences in pain perception and analgesia. Aim 1 will determine ethnic group differences in perceptual and physiological responses to acute post-operative pain and examine how those are related to genetic, pre-operative psychophysical and psychosocial factors. Aim 2 will determine ethnic differences in opioid analgesia and side effects and examines genetic, pharmacokinetic (PK), pharmaco-dynamic (PD), and psychosocial factors that explain group differences in analgesic responses. In response to NOT-OD-09-056, Notice of Availibility of Recovery Act Funds for Administrative Supplements, this supplement project aims to: (1) Create employment through three positions (e.g. full time, increase of half time position to full time, a contractural position for specialized technical skills); (2) Increase the tempo of scientific discovery by including additional minorities in recruitment, thus also making the findings more applicable across populations; (3) Advance the pace of the parent grant by engaging in rapidly developing genetic and PK/PD technology and also stimulating biomedical economic growth through use of supplies and equipment; (4) Achieve the K01 training plan goals by moving the PI closer to scientific independence by accomplishing recruitment, manuscript production and completing an R01 submission; (5) Solidify a strong investigative team for longevity and growth toward novel scientific discovery and increased presence in the local, academic and research communities; and (6) Grow investigation in translational science of pain through enhanced collaborations and advance the tempo of science to reduce health disparities in clinical pain through the development of interventions designed to improve acute pain and enhance analgesic response for improved quality of life across ethnic groups for those who receive suboptimal pain care.