This award is an administrative supplement for a Career Transition Award from the Center to Reduce Cancer Health Disparities at NCI to promote the advancement of minority scientist towards independence and research on health disparities related issues. This award increases the chances of successfully completing the goals of the Transition Career Award as it accelerates discovery and increases outcomes, thus indirectly supports the mission of this center. The present funding is under the umbrella of a project titled: ”Tumor Endothelium Marker 8 mediated adhesion in tumor associated vasculature”, which aims to elucidate the role of this cell surface molecule in tumor vasculature, by studying the function of this marker at the molecular level. This molecule is of high interest as a therapy-targeting candidate because of its selective induction in endothelial cells associated with tumor vasculature. This molecule is of further interest as it is a receptor for anthrax toxin, mediating the entrance of the toxin into the cell. We have found that expression of this molecule alters the way cells interact with their environment. We are studying the role that this alteration plays in blood vessel formation and function using cultured blood vessel lining cells and in vivo models for blood vessel formation with the hypothesis that these mechanisms operate in tumor endothelium as well and thereby provide novel therapeutic strategies.