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REGENTS OF THE UNIVERSITY OF COLORADO, THE

The overarching goal of the Colorado Adoption Project (CAP) is to assess the genetic and environmental etiologies of individual differences in behavioral development. Toward this end, adoptive and nonadoptive probands and siblings have been tested almost yearly from birth through their early 20's. The proposed continuation of HD010333 will provide for a 10-year follow-up of 682 CAP probands and siblings, now in their early 30's, and the culmination of testing of participants from infancy through early adulthood. The primary objective of this competitive renewal of the CAP is to achieve a better understanding of the interplay among factors of childhood and adolescence which combine and interact to influence relevant outcomes of early adulthood, including those that may inform studies of later adult development, such as cognitive performance, cognitive change/decline, physical health, emotional well-being, career/job satisfaction, economic well-being, and interpersonal relationships. Specifically, we will assess adult outcomes of behavioral development, and factors that may mediate or moderate these outcomes. We will draw on our wide array of childhood measures to assess adult outcomes of child behavioral development, as well as mediating or moderating influences. Further, we will explore issues of genetic and environmental contributions to adulthood behaviors from a developmental perspective, and will examine gene-environment correlation and interaction. Thus, the continuation of HD-10333 will result in a landmark adoption study of behavioral development, spanning infancy through early adulthood, the magnitude and quality of which are unparalleled. PUBLIC HEALTH RELEVANCE: This unparalleled adoption study will contribute to a better understanding of the interplay among factors of childhood and adolescence which combine and interact to influence important outcomes of adulthood, including factors which contribute to physical and emotional health. An improved understanding of genetic and environmental influences, and how they interact with early life factors to affect adult health, may contribute to improved health and well-being as well as to better health education and services.

Clarification of Codes