This is an administrative supplement request for parent grant "Identifying Mechanisms of Dementia: Role for MRI in the Era of Molecular Imaging", R01 AG11378. The performance dates of the parent grant are 9/1/2008-7/31/2013. The overall goal of this parent grant is to use imaging proxies to identify specific pathological mechanisms underlying progression to dementia. AG11378 will generate over 50,000 image files. Each of these must undergo quality control (QC) and have provenance information recorded. The overall objective of this Administrative Supplement is to improve the organization and efficiency of image QC and information management systems for AG11378. The entire focus of this Administrative Supplement will be on developing and testing new software tools. We will use the Administrative Supplement funds to hire two new software programmers who will be recent graduates of BS or MS computer science programs. These will be high technology and value positions that will newly be added to the economy. Neither of these positions will exist in the absence of funding for this Administrative Supplement. Development of the automated image QC tools, provenance tracking tools, and data management tools proposed in this administrative supplement will clearly accelerate data throughput for the parent grant, AG11378. The new systems proposed in this supplement will eliminate the need for thousand of hours of manual file manipulation and inefficient image inspection and thus reduce errors and improve overall data quality. Therefore this supplement will met the two major criteria for ARRA funds for administrative supplements - job creation and accelerating the tempo of scientific research in the parent grant. In addition however, the methods for image QC and data management developed by the supplement will be leveraged for other major NIA grants for which the Mayo Clinic serves as the central MRI lab. These are the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer's Network (DIAN). Finally, the software tools developed in this Administrative Supplement will be used to establish QC methods and improve information management for imaging in therapeutic trials sponsored by the pharmaceutical industry, thus providing a third layer of leveraging of these supplement funds.