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ILLINOIS INSTITUTE OF TECHNOLOGY

Funds were requested as an administrative supplement using ARRA funds in order to ?accelerate the tempo of scientific research? by providing additional effort for the Project"BioCAT - Biophysics Collaborative Access Team" from NCRR with an emphasis on aims 1a ? Combined SAXS/ WAXS for improved throughput, 1e ?High throughput static SAXS modes with sample robot and micro-fluidics.?, and 2b ?Turbulent flow mixer for continuous flow, high time resolution studies?. Aims 1a, 1b and 1e are all aimed at making SAXS data collection on the BioCAT beamline 18ID more efficient as well to increase the information content of the individual measurements. Aim 2B has a different goal, namely making a new range of time scales of time resolved studies (down to ca. 100 microseconds) practical for a larger range of scientific problems than hitherto by reducing the sample requirements from the gram quantities needed now in the current configuration down to a few 10?s of milligrams. Prior to these developments, time resolved experiments could only be done on relatively inexpensive commercially available proteins and nucleic acids whereas the planned developments would allow kinetic studies of a much broader range of biomedically important samples. The goal is to make these capabilities available a year sooner than would have been possible without these supplemental funds.

Clarification of Codes