TRUSTEES OF INDIANA UNIVERSITY
Acute kidney injury (AKI) is a tremendous burden on human health and health care resources. Acute alterations of the kidney microvasculature significantly contribute to kidney dysfunction during AKI. In addition, there is growing evidence that chronic alterations of the kidney microvasculature following an episode of AKI are directly related to long-term kidney dysfunction and a propensity towards chronic kidney disease.
There is a fundamental gap in understanding the mechanisms responsible for these acute and chronic microvascular alterations. The long term goal is to understand the cellular and molecular basis of renal microvascular alterations associated with AKI and to develop novel and specific therapeutic interventions targeting these mechanisms. The objective of this supplement, which is a step towards attainment of the long term goal, is to provide supplemental funding through the American Recovery and Reinvestment Act of 2009
(ARRA) for new additional personnel to accelerate key aspects of the scientific aims of the parent R01 “Mechanisms of Microvascular Damage in Acute Kidney Injury”. The overall objective of this supplement will be accomplished by pursuing two specific aims. Aim 1 will be to employ additional personnel with needed skills to accelerate key studies in scientific aim 1 of the parent R01. To accomplish this aim, we will recruit a postdoctoral fellow from a number of applicants who have recently applied to the laboratory. The postdoctoral fellow will spearhead key uncompleted studies described in scientific aim 1 of the parent R01 and thus accelerate the overall progress of the parent R01. Aim 2 will be to retain and increase effort of current personnel to accelerate important studies in scientific aim 2 of the parent R01 and extend significant findings from this aim. To accomplish this aim, one of the current research technicians will be increased from 50% to 100% FTE in order to not only retain but expand their percent effort and thus provide personnel to accelerate finishing scientific aim 2 of the parent R01 and to work on extending key findings of this aim. The proposed supplement is significant because it is expected to promote job creation, support job retention, and provide personnel to accelerate the pace and achievement of scientific research proposed in the parent R01.