UNIVERSITY OF ARKANSAS SYSTEM
Regulation of caspase-1 by Sod2 in the heart? Apoptosis of cardiomyocytes is increased in human heart failure, and several studies have subsequently suggested that cardiomyocyte apoptosis is a central mechanism in heart failure. The exploratory studies proposed in this project will demonstrate a novel function of a well known antioxidant enzyme in the control of inflammatory caspase-1 expression. The outcome of these studies may help in the therapeutic use of MnSOD or substances that induce MnSOD in the protection of myocardial injury in heart failure, endothelial dysfunction or other cardiovascular diseases.