UNIVERSITY OF ARKANSAS SYSTEM
A SonoKnife for Advanced Cancers. Development of a new technology for non-invasive thermal ablation of superficial head and neck tumors or positive lymph nodes, namely, a SonoKnife, a scanned, line-focused ultrasound thermal therapy system (target temperatures of 50-60C).
Choose a quarter and click "Go."
| AWARD OVERVIEW |
| Award Number |
1 RC1 CA147697-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$994,117 |
Project Location - City |
Little Rock |
| Award Date |
09/29/2009 |
Project Location - State |
AR |
| Project Status |
Completed |
Project Location - Zip |
72205-7199
|
| Jobs Reported |
0.00 |
Congressional District |
02 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF ARKANSAS SYSTEM |
| Recipient DUNS Number |
122452563
|
| Recipient Address |
4301 W MARKHAM ST ST63 |
| Recipient City |
LITTLE ROCK |
| Recipient State |
Arkansas |
| Recipient Zip |
72205-7101 |
| Recipient Congressional District |
02 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
A SonoKnife for Advanced Cancers |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
Theoretical: A heterogeneous model has been under development. Results thus far have shown significantly improved agreement between in vivo measurements and numerical simulations. Briefly, the heterogeneous model predicts temperatures that would cause cutaneous burns similar to those seen in the in vivo studies.
Experimental: We have performed one more in vivo experiment with the 3.5 MHz transducer and aggressive skin, but we were not able to avoid skin burns successfully. As mentioned before, the fat layer of the porcine skin easily burns at the high frequency (3.5 MHz) even with aggressive cooling. The thicker the fat layers the worst the burn.
Summary of Research: If the porcine skin is a good model for the human skin at the ultrasonic frequencies employed, then our device may not be suitable for treating shallow tumors without compromising overlying healthy skin tissues. This finding seriously compromises the application of the SonoKnife for the treatment of superficial head and neck cancerous tumors. Other potential applications have been discussed in our recently published paper (see below).
Publications and Presentations:
Chen D, Xia R, Chen X, Shafirstein G, Corry P, Griffin RJ, Penagaricano JA, Tulunay-Ugur OE, Moros EG. SonoKnife: Feasibility of a line-focused ultrasound device for thermal ablation therapy. Medical Physics, 2011;38(7):4372-4385. doi:10.1118/1.3601017
The PI presented results as an Invited Speaker at the American Association of Physicists in Medicine in Vancouver, Canada (July 31 to August 4) in a special Therapeutic Ultrasound Symposium. Drs. Duo Chen, Xin Chen and Gal Shafirstein continue to develop an invited paper to the International Journal of Hyperthermia. Dr. Chen has been working on this paper which focuses on the need to include heterogeneities in the acoustic models for proper treatment planning for the SonoKnife. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
no jobs were created or retained this quarter. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
09/29/2009 |
| Award Number |
1 RC1 CA147697-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$994,117 |
| Funds Invoiced/Received |
$994,117 |
| Expenditure Amount |
$994,117 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
0 |
| Total Amount of payments to vendors less than $25,000/award |
$0 |
| Location Information |
| Latitude, Longitude |
34º 45' 5",
-92º 19' 15" |
| Congressional District |
02 |
| Address 1 |
4301 West Markham |
| Address 2 |
|
| City |
Little Rock |
| County |
Pulaski |
| State |
AR |
| Zip |
72205-7199 |
|
|