TITLE: Role of Syk and Rac2 in regulation of HIF1alpha and neovascularization Postnatal neovascularization plays a critical role in pathogenesis of numerous diseases e.g. diabetic retinopathy, tissue remodeling upon injury, rheumatoid arthritis and tumor growth. Hypoxia induced HIF1a stabilization and its target genes (e.g. VEGF) are important factors for postnatal neovascularization. It has been established that EC plays a most vital role in these processes. The major objective of this proposal is to determine the role of endothelial specific Syk-Rac2 signaling axis in cell migration and postnatal neovascularization via the stabilization of HIF1a. At the end of this study, we will establish an endothelial cell specific signaling axis, which is more effective/superior target as a novel therapeutic option for the treatment of postnatal neovascularization. This research will lead to the identification of new methods for the treatment of vascular diseases such as coronary artery disease and sickle cell disease.