TRUSTEES OF INDIANA UNIVERSITY
This application proposes the purchase of a new bone histomorphometry system (OsteoMeasure XP Advanced System) consisting of a digital video analysis system and a fluorescence microscope. This equipment will allow the PI of this application, Dr. Bellido, and personnel in her laboratory to increase the speed in the analysis of experiments proposed under the parent grant entitled “Osteocyte control of bone formation via Sost”.
The scope of the project is the same as the one formulated in the parent grant. The overall goal of the project is to advance understanding of the control of bone formation by osteocytes and to elucidate the contribution of these cells to the osteoblastogenic actions of PTH, PTHrP, and mechanical stimuli.
The hypothesis to be tested is that activation of PTHR1 signaling in osteocytes leads to a rapid and direct inhibition of Sost expression, which, in turn, is responsible for increased bone formation in response to systemic elevation of PTH as well as to bone loading through local increase in PTHrP.
| AWARD OVERVIEW |
| Award Number |
3R01DK076007-03S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$76,670 |
Project Location - City |
INDIANAPOLIS |
| Award Date |
02/22/2010 |
Project Location - State |
IN |
| Project Status |
Completed |
Project Location - Zip |
46202-5120
|
| Jobs Reported |
0.00 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
TRUSTEES OF INDIANA UNIVERSITY |
| Recipient DUNS Number |
603007902
|
| Recipient Address |
620 UNION DR RM 618 |
| Recipient City |
INDIANAPOLIS |
| Recipient State |
Indiana |
| Recipient Zip |
46202-5130 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Osteocyte Control of Bone Formation via Sost |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) |
| Quarterly Activities/Project Description |
This award supported the purchase of a new bone histomorphometry system (OsteoMeasure XP Advanced System) consisting of a digital video analysis system and a fluorescence microscope and additional small instruments. This equipment allowed the PI of this application, Dr. Bellido, and personnel in her laboratory to increase the speed in the analysis of experiments proposed under the parent grant entitled “Osteocyte control of bone formation via Sost”.
The hypothesis to be tested is that activation of PTHR1 signaling in osteocytes leads to a rapid and direct inhibition of Sost expression, which, in turn, is responsible for increased bone formation in response to systemic elevation of PTH as well as to bone loading through local increase in PTHrP.
We continue to use the equipment purchased with this award in a very active way. Several abstracts were presented reporting the work performed, one study was published, another study was submitted for publication and is being reviewed after a revision, and three other manuscripts reporting work being completed are under preparation. This has been indicated in the final progress report already submitted to the NIH. Work is complete and this is the final report |
| Jobs Created |
0.00 |
| Description of Jobs Created |
No jobs created/retained |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0883 |
| Award Information |
| Award Date |
02/22/2010 |
| Award Number |
3R01DK076007-03S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$76,670 |
| Funds Invoiced/Received |
$76,670 |
| Expenditure Amount |
$76,670 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
541712 |
| Activity Description |
Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology) |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$53,507 |
| Number of payments to vendors less than $25,000/award |
4 |
| Total Amount of payments to vendors less than $25,000/award |
$18,822 |
Osteometrics Inc - Award Number 3R01DK076007-03S1 - Osteometrics Inc
| Award Number |
3R01DK076007-03S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
845071950 |
| Vendor HQ Zip Code + 4 |
30030-1254 |
| Vendor Name |
Osteometrics Inc |
| Product and Service Description |
Analytical Laboratory Instrument Manufacturing |
| Payment Amount |
$53,507 |
| Location Information |
| Latitude, Longitude |
39º 46' 34",
-86º 10' 42" |
| Congressional District |
07 |
| Address 1 |
MS 5035A, |
| Address 2 |
|
| City |
INDIANAPOLIS |
| County |
Marion |
| State |
IN |
| Zip |
46202-5120 |
|
|