ARKANSAS STATE UNIVERSITY
This interdisciplinary effort integrates faculty, post-doctoral and student researchers in the disciplines of biochemistry, immunology, physiology, molecular cell biology, neurobiology, and plant biology.
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| AWARD OVERVIEW |
| Award Number |
0960089 |
Funding Agency |
National Science Foundation |
| Total Award Amount |
$1,070,851 |
Project Location - City |
Jonesboro |
| Award Date |
01/20/2010 |
Project Location - State |
AR |
| Project Status |
More than 50% Completed |
Project Location - Zip |
72401-1327
|
| Jobs Reported |
0.29 |
Congressional District |
01 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
ARKANSAS STATE UNIVERSITY |
| Recipient DUNS Number |
073510067
|
| Recipient Address |
2010 AGGIE RD |
| Recipient City |
STATE UNIVERSITY |
| Recipient State |
Arkansas |
| Recipient Zip |
72467-1260 |
| Recipient Congressional District |
01 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
MRI-R2: Acquisition of equipment for investigating biodynamic interactions |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Science & Technology N.E.C. |
| Quarterly Activities/Project Description |
At 95% complete, equipment is in place & technology is integrated. Adjusting to loss of key staff with approaches to ensure technical expertise is maintained & instruments & knowledge base are sustainable. Focus on research & increasing impact of instruments through utilization by students, staff, & faculty & broadening use to new project areas, with emphasis on sustainability. All instruments comprising the immuno/cell biology cluster are used in support of MRI research goals. New policies ensuring security, training, & responsible use were developed this quarter to be instituted next quarter. Project 3 Cramer/Dolan: A mouse trial involving intranasal vaccination of a model antigen (OVA) & plant-made interleukin 12 was completed. The goal was to assess immune baselines for strong cell-mediated response comparing vaccination in the presence of different adjuvants. Spleens & regional lymph nodes were collected & used to establish primary cultures for analysis by flow cytrometry. The Miltenyi Biotec gentleMACS Dissociator was critical for processing samples providing excellent homogeneity & viability. Analyses demonstrated IL-12 mediated shift in immunity toward CMI with plant-derived cytokine & will support a publication on in vivo efficacy of plant-made product. Upgrades to BD Pathway 855 Bioimaging System enabled development of powerful new assay for assessing enzyme delivery & disease phenotype correction in a cell model of human lysosomal storage disease (Acosta & Cramer). Fibroblasts (normal, Hurler syndrome, & Hurler/Scheie syndrome) were labeled with DAPI (labels nuclei to define ?one cell?) & with Lysotracker-red to stain lysosomes. Demonstrated that lysosomal area per cell was significantly different between normal & diseased fibroblasts & enzyme-mediated lysosomal ?correction? of phenotype could be effectively quantified. The assay provides significant advantages in statistical measurement & efficiency (replaces a 4 week protocol with a 4 day protocol). |
| Jobs Created |
0.29 |
| Description of Jobs Created |
Technical staff for the project who took on oversight and maintenance of the MRI-purchased instruments. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
49-0101 |
| Award Information |
| Award Date |
01/20/2010 |
| Award Number |
0960089 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
49 |
| Funding Agency Name |
National Science Foundation |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
49 |
| Awarding Agency Name |
National Science Foundation |
| Amount of Award |
$1,070,851 |
| Funds Invoiced/Received |
$980,481 |
| Expenditure Amount |
$985,921 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
U99 - NTEE |
| Activity Description |
Science & Technology N.E.C. |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
1 |
| Total Amount of payments to vendors less than $25,000/award |
$2,750 |
| Location Information |
| Latitude, Longitude |
35º 50' 34",
-90º 40' 57" |
| Congressional District |
01 |
| Address 1 |
504 University Loop East |
| Address 2 |
|
| City |
Jonesboro |
| County |
Craighead |
| State |
AR |
| Zip |
72401-1327 |
|
 |