UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER
This application addresses broad Challenge Area (04) Clinical Research and specific Challenge Topic 04-AR-101 Autoimmunity for Diseases of Skin, Joints, Muscles and Other Tissues. It is estimated that approximately 5% of the US population is affected by an autoimmune disorder such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or multiple sclerosis (MS). These conditions cause considerable morbidity and excess mortality, as well as direct and indirect health care costs in the tens of billions of dollars. The diagnosis of these conditions is often difficult, requiring multiple visits to medical specialists, and the interpretation of imperfect tests. Even when the diagnosis is certain, the tools to offer prognosis or personalize therapy are often lacking. The overall goal of this project is to rapidly and thoroughly evaluate a novel technology for the measurement of antibodies specific for SLE, a model for systemic autoimmunity. The technology is based on the ability of synthetic polymers of N-substituted glycine termed 'peptoids' to serve as specific ligands for immunoglobulin. Two specific aims will be undertaken: 1) Validation of a novel technology platform for IgG biomarker discovery using systemic lupus erythematosus as a model, and 2) Determine the ability of peptoid ligands to identify pre-clinical autoimmunity. To accomplish these aims, highly specific peptoid ligands will be synthesized, purified and attached to fluorescent beads to create a high-throughput screening platform. They will then be used to measure and characterize autoantibodies from subjects with clinically evident SLE as well as those with early or incomplete forms of the disease. Together, the results of this study will lead to the development of new tools for clinicians and clinical researchers to use in the assessment of autoimmune diseases. PUBLIC HEALTH RELEVANCE: Autoimmune diseases are common causes of illness that are difficult to diagnose and monitor. This study will test a completely new method to monitor changes in the composition of the blood of patients with systemic lupus erythematosus. Using this as a model system, it is hoped that other autoimmune diseases will benefit from early diagnosis and treatment.
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| AWARD OVERVIEW |
| Award Number |
1RC1AR058817-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$974,414 |
Project Location - City |
Dallas |
| Award Date |
09/21/2009 |
Project Location - State |
TX |
| Project Status |
Completed |
Project Location - Zip |
75390-9020
|
| Jobs Reported |
0.00 |
Congressional District |
30 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER |
| Recipient DUNS Number |
800771545
|
| Recipient Address |
5323 HARRY HINES BLVD |
| Recipient City |
DALLAS |
| Recipient State |
Texas |
| Recipient Zip |
75390-7208 |
| Recipient Congressional District |
30 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
High Throughput Screening of Autoimmune Epitome - ARRA Stimulus Challenge Grant |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Specialties Research |
| Quarterly Activities/Project Description |
The final Total ARRA Expenditure for this project is less than the Award Amount.The project was completed under budget.No more funds will be expended.We have tested the ability of newly discovered synthetic antigens to detect autoantibodies in different subject groups. In general, reactivity to the peptoid corresponded to the presence of classically defined anti-nuclear antibodies. The anti-peptoid antibody was purified on a peptoid column and tested for reactivity to a panel of ~100 known autoantigens printed on a microarray. There appears to be poly-reactivity to antigens that are known to bind DNA or RNA. While this is not unexpected, it documents the validity of the approach used to detect autoantibodies, and the final identity of the authentic protein antigens is underway. However, we have detected anti-peptoid reactivity in a small set of first-degree relatives of lupus patients. These subjects were healthy at the time of blood donation and did not have an ANA. They are genetically predisposed to autoimmunity. The reactivity seen with the peptoid ligands may represent the first evidence of altered humoral immunity in these people who may go on to develop clinically apparent disease. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
N/A |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0903 |
| Award Information |
| Award Date |
09/21/2009 |
| Award Number |
1RC1AR058817-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$974,414 |
| Funds Invoiced/Received |
$967,614 |
| Expenditure Amount |
$967,614 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H03.07 |
| Activity Description |
Medical Specialties Research |
| Sub-Awards Information |
| Sub-awards to Organizations |
2 |
| Sub-award Amounts to Organizations |
$471,582 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
222 |
| Total Amount of payments to vendors less than $25,000/award |
$513,975 |
Sub-award GMO 100818 - PENNSYLVANIA STATE UNIVERSITY, THE
| Sub-Award Amount |
$24,120 |
| Sub-Award Date |
07/01/2010 |
| Sub-Awards Disbursed |
$20,041.68 |
| Project Location - City |
Hershey |
| Project Location - State |
PA |
| Project Location - Zip Code |
17033-2360 |
| Project Location - Congressional District |
15 |
| Sub-Recipient DUNS Number |
129348186
|
| Sub-Recipient Address |
500 UNIVERSITY DR C1607 |
| Sub-Recipient City |
HERSHEY |
| Sub-Recipient State |
Pennsylvania |
| Sub-Recipient Zip Code |
17033-2360 |
| Sub-Recipient Congressional District |
15 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award GMO 100908 - SCRIPPS RESEARCH INSTITUTE, THE
| Sub-Award Amount |
$447,462 |
| Sub-Award Date |
09/21/2009 |
| Sub-Awards Disbursed |
$447,461.82 |
| Project Location - City |
Jupiter |
| Project Location - State |
FL |
| Project Location - Zip Code |
33458-5284 |
| Project Location - Congressional District |
18 |
| Sub-Recipient DUNS Number |
781613492
|
| Sub-Recipient Address |
10550 N TORREY PINES RD |
| Sub-Recipient City |
LA JOLLA |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
92037-1000 |
| Sub-Recipient Congressional District |
49 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
32º 48' 45",
-96º 50' 18" |
| Congressional District |
30 |
| Address 1 |
5323 Harry Hines BLVD |
| Address 2 |
|
| City |
Dallas |
| County |
Dallas |
| State |
TX |
| Zip |
75390-9020 |
|
 |