Explore and establish a web service or platform that serves as a common user interface. Current software was developed indepently by various labs using different third party libraries and coding languages ( C++, Java, Matlab and R) and using a variety of data formats. We will integrate these into a system with a unified interface, using common tools such as Systems Biology Markup Language (SBML) and hiding the complexity in supporting libraries/languages in a computing server environment. (2) Provide documented open source stand-alone packages for the local installation of individual components. (3) Develop user-oriented documentation and working examples, targeting users with little or no programming expertise, material will include hands-on and reproducible examples from DCSB research projects, and will be extensible for new projects. (4) Optimize and translate components of existing code for improved usability and effiency, converting high-level code such as R/Matlab to more efficient alternatives such as Java and C++. (5) For more computing-intensive algorithms that some of the models and methods are based on, explore and develop parallel implementations via cluster computing and multi-core multi-threading algorithms.