UNIVERSITY OF ARKANSAS SYSTEM
The objective of this project is to use novel quantitative proteomic method to systematically identify Bax interacting proteins that may play critical roles in keeping Bax in check in the cytosol of healthy cells. The identifications of novel Bax interacting, death regulatory proteins are critical for understanding the molecular mechanisms of Bax activation in apoptosis. Molecular and cell biological techniques will be used to assess the biological functions of the identified proteins.