BAYLOR RESEARCH INSTITUTE, THE
Vaccines represent the major success of immunology and have spared countless numbers of people from infections. Despite this success, we understand little about how effective vaccines stimulate protective immune responses. We surmise that understanding the modus operandi of vaccines in healthy people and understanding their shortcomings by studying hypo-responsive people will permit us to unravel the immunological principles of vaccination. Three vaccines will be studied in great detail: inactivated influenza vaccine and hepatitis B vaccine with either alum as the traditional adjuvant (Engerix) or with CPGoligonucleotide (Heplisav). We surmise that systems biology approaches will permit us to gain a comprehensive view of the immunobiology associated with a potent response to vaccination. This will lead to the identification of biomarker signatures indicative of the quality of vaccine-induced antibody responses. This, in turn, will facilitate the rational design and development of novel improved vaccines. Our preliminary studies performed with 24 healthy volunteers indicate that three commercially available vaccines: Fluzone (influenza), Pneumovax and Engerix alter the blood cell composition and transcriptome in completely different ways. These preliminary results support our proposed strategy. They demonstrate that the different vaccines, which are able to induce protective humoral responses, mobilize different immune effectors. We propose five highly integrated projects which will be supported by seven cores.
| AWARD OVERVIEW |
| Award Number |
1U19AI089987-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$4,499,507 |
Project Location - City |
Dallas |
| Award Date |
07/12/2010 |
Project Location - State |
TX |
| Project Status |
Completed |
Project Location - Zip |
75204-6153
|
| Jobs Reported |
11.08 |
Congressional District |
30 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
BAYLOR RESEARCH INSTITUTE, THE |
| Recipient DUNS Number |
145745022
|
| Recipient Address |
3310 LIVE OAK STE 501 |
| Recipient City |
DALLAS |
| Recipient State |
Texas |
| Recipient Zip |
75204-6134 |
| Recipient Congressional District |
30 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Allergy & Immunological Diseases |
| Quarterly Activities/Project Description |
The overall goal of our Center is to apply systems biology approaches to study immune responses to vaccination in healthy and immunocompromised populations. This in turn will permit us to define vaccine responders and non-responders and develop biomarker signatures predictive of vaccine response.
The specific goals are to:
1. Define the parameters of a ?resting? immune system in healthy populations.
2. Define the parameters of ?resting? immune system in diseased populations.
3. Define the parameters of response to vaccination.
4. Define the parameters that predict effective vaccine responses.
Working towards these goals, in the last quarter, we have launched studies both in healthy volunteer cohorts and in the cohorts of subjects with disease including patients undergoing autologous hematopoietic cell transplant and in children with autoimmune diseases. We have also launched the clinical study with hepatitis B vaccination. This will allow us to identify the molecular signatures of low and high vaccine responders as measured by antibody titers. Knowledge gained will be used to design improved vaccines but perhaps more importantly also to establish biomarkers able to predict low and high responders. Projects including the analysis of cell subsets purified from blood before and after vaccination with flu vaccine to identify pathways activated in response to vaccination are ongoing and mechanistic studies are underway. Finally, we are developing a novel assay allowing analyzing the status of the innate immunity in human blood. Once validated, this assay will be applied in all our clinical studies to test its predictive value in assessing response to vaccination. This is important because the innate immune response dictates the quality of adaptive immune response, that is, T cells and neutralizing antibodies.
No further updates as this concludes ARRA funding for this study. |
| Jobs Created |
11.08 |
| Description of Jobs Created |
0.8 FTE PhD Scientists
2.5 FTE Post doctoral fellow
1 FTE Biostatistician
5 FTE Research Assistants
.25 FTE VP(PD/PI)
.01 VP
.2 Sr. Scientist
1 FTE Programmer Analyst
.50 Grad Student
|
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0900 |
| Award Information |
| Award Date |
07/12/2010 |
| Award Number |
1U19AI089987-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$4,499,507 |
| Funds Invoiced/Received |
$4,499,507 |
| Expenditure Amount |
$4,499,507 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
G02.02 |
| Activity Description |
Allergy & Immunological Diseases |
| Sub-Awards Information |
| Sub-awards to Organizations |
5 |
| Sub-award Amounts to Organizations |
$1,004,315 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
0 |
| Total Amount of payments to vendors less than $25,000/award |
$0 |
Sub-award 41010001002 - DYNAVAX TECHNOLOGIES CORPORATION
| Sub-Award Amount |
$461,051 |
| Sub-Award Date |
08/13/2010 |
| Sub-Awards Disbursed |
$461,050.60 |
| Project Location - City |
Berkeley |
| Project Location - State |
CA |
| Project Location - Zip Code |
94710-2753 |
| Project Location - Congressional District |
09 |
| Sub-Recipient DUNS Number |
964173801
|
| Sub-Recipient Address |
2929 7TH ST STE 100 |
| Sub-Recipient City |
BERKELEY |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
94710-2753 |
| Sub-Recipient Congressional District |
09 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 41010001013 - MOUNT SINAI SCHOOL OF MEDICINE
| Sub-Award Amount |
$152,124 |
| Sub-Award Date |
01/10/2011 |
| Sub-Awards Disbursed |
$152,124.00 |
| Project Location - City |
New York |
| Project Location - State |
NY |
| Project Location - Zip Code |
10029-6574 |
| Project Location - Congressional District |
14 |
| Sub-Recipient DUNS Number |
078861598
|
| Sub-Recipient Address |
1 GUSTAVE L LEVY PRICE |
| Sub-Recipient City |
NEW YORK |
| Sub-Recipient State |
New York |
| Sub-Recipient Zip Code |
10029-6500 |
| Sub-Recipient Congressional District |
14 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 41010001014 - MOUNT SINAI SCHOOL OF MEDICINE
| Sub-Award Amount |
$101,700 |
| Sub-Award Date |
09/27/2010 |
| Sub-Awards Disbursed |
$101,700.00 |
| Project Location - City |
New York |
| Project Location - State |
NY |
| Project Location - Zip Code |
10029-6574 |
| Project Location - Congressional District |
14 |
| Sub-Recipient DUNS Number |
078861598
|
| Sub-Recipient Address |
1 GUSTAVE L LEVY PRICE |
| Sub-Recipient City |
NEW YORK |
| Sub-Recipient State |
New York |
| Sub-Recipient Zip Code |
10029-6500 |
| Sub-Recipient Congressional District |
14 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 41010001012 - RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
| Sub-Award Amount |
$144,000 |
| Sub-Award Date |
08/11/2010 |
| Sub-Awards Disbursed |
$143,930.17 |
| Project Location - City |
Columbus |
| Project Location - State |
OH |
| Project Location - Zip Code |
43205-2696 |
| Project Location - Congressional District |
12 |
| Sub-Recipient DUNS Number |
147212963
|
| Sub-Recipient Address |
700 CHILDRENS DR |
| Sub-Recipient City |
COLUMBUS |
| Sub-Recipient State |
Ohio |
| Sub-Recipient Zip Code |
43205-2664 |
| Sub-Recipient Congressional District |
12 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 41010001015 - UNIVERSITY OF CALIFORNIA, SANTA CRUZ
| Sub-Award Amount |
$145,440 |
| Sub-Award Date |
08/09/2010 |
| Sub-Awards Disbursed |
$145,440.00 |
| Project Location - City |
Santa Cruz |
| Project Location - State |
CA |
| Project Location - Zip Code |
95064-1077 |
| Project Location - Congressional District |
17 |
| Sub-Recipient DUNS Number |
125084723
|
| Sub-Recipient Address |
1156 HIGH ST |
| Sub-Recipient City |
SANTA CRUZ |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
95064-1077 |
| Sub-Recipient Congressional District |
17 |
Required To Report Top 5
Highly Compensated Officials |
No |
| Location Information |
| Latitude, Longitude |
32º 47' 32",
-96º 47' 5" |
| Congressional District |
30 |
| Address 1 |
Baylor Research Institute |
| Address 2 |
3434 Live Oak |
| City |
Dallas |
| County |
Dallas |
| State |
TX |
| Zip |
75204-6153 |
|
 |