MASSACHUSETTS INSTITUTE OF TECHNOLOGY
This ARRA project is a supplement to ES16313, The Environment as an Experimental Variable to Calibrate Mouse Models of Human Disease. It supported the work of Ms. Ann Wattanawaraporn, a graduate student, who collaborated with Prof. John Groopman of Johns Hopkins University in the use of Stable Isotope Mass Spectrometry, or SIMS, to correlate the levels of DNA damage by carcinogens (initially aflatoxin B1) with the levels of mutations induced by such agents. The work has been successful and half of it has just appeared in print. The project compared the adduct and mutation levels in mice at three and ten weeks post injection of the toxin to four day old mice.