WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
Cocaine and methamphetamine are leading drug threats in the U.S. today, yet no effective treatments for their abuse are available. Parent grant information: The specific aims of the parent grant tests the hypothesis that beta receptors represent viable medication development targets for psychostimulant abuse. Novel compounds are synthesized by the medicinal chemists on the research team, and the resulting compounds are evaluated using in vitro and in vivo assays by the pharmacologists. Administrative supplement information: An administrative supplement for equipment is requested to accelerate the testing of novel beta ligands that are being developed by our research group. The compounds have the potential to mitigate the effects of psychostimulant drugs, such as cocaine and methamphetamine. A Chameleon V multilabel plate reader will be purchased to increase throughput and create additional efficiencies in the evaluation of our novel compounds. Recovery act information: The current request would be consistent with accelerating the tempo of research in the NIDA scientific priority area of medications and immunotherapies. It would stimulate the economy by enabling the purchase of needed equipment costing under $100,000. The resulting work generated also has the potential to impact the states of West Virginia and Maryland with regard to patents, potential company formations, as well as increased extramural research funding and associated job creation.