UNIVERSITY OF WASHINGTON
Low back pain is one of the most important causes of functional limitation and disability, an Institute of Medicine priority condition, and it remains a particularly important problem for the elderly, an AHRQ priority population. While there are numerous guidelines regarding the use of diagnostic testing and treatments for the general low back pain population, there is a paucity of evidence-based guidelines for the elderly. This is more than a mere academic concern. The annual direct medical costs of low back pain were $86 billion in 2005 and by 2010 are likely to rise over $100 billion. Despite the high prevalence and cost of low back pain, important questions remain unanswered regarding the comparative effectiveness of most commonly used diagnostic tests and treatments. Our primary goal is to establish a large, community-based registry of elderly patients with low back pain. This registry will provide a foundation for rigorous prospective studies including large, practical, randomized controlled trials (RCTs). Alongside the registry, we propose to enroll patients into two studies: 1) an RCT of elderly patients with spinal stenosis to evaluate the effectiveness, cost and safety of combined epidural steroid injections and local anesthetic compared with local anesthetic injections alone, and 2) a prospective observational cohort study of early advanced imaging (MRI and CT) compared to no advanced imaging in elderly patients with new episodes of low back pain. These studies will serve as demonstration projects for the value of the registry for comparative effectiveness research. The registry will provide the infrastructure for future studies to evaluate back pain care at multiple stages of development, from the early market penetration of relatively immature technologies (e.g. artificial discs, genomics) to widely disseminated mature interventions (e.g. MRI, physical therapy, spinal fusion). The overall goal of this project is to establish a sustainable and rich registry to evaluate prospectively the effectiveness, safety, and cost-effectiveness of interventions for patients over age 65 with low back pain.
Choose a quarter and click "Go."
| AWARD OVERVIEW |
| Award Number |
1R01HS01922201 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$9,887,064 |
Project Location - City |
SEATTLE |
| Award Date |
09/28/2010 |
Project Location - State |
WA |
| Project Status |
More than 50% Completed |
Project Location - Zip |
98195-0000
|
| Jobs Reported |
31.36 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF WASHINGTON |
| Recipient DUNS Number |
605799469
|
| Recipient Address |
4333 BROOKLYN AVE NE |
| Recipient City |
SEATTLE |
| Recipient State |
Washington |
| Recipient Zip |
98195-0001 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Back pain Outcomes using Longitudinal Data (BOLD) |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
The LESS RCT: The RCT is actively recruiting subjects at sixteen sites: Brigham and Women's Hospital, Harvard Vanguard Medical Associates, Massachusetts General Hospital and St. Elizabeth's Medical Center in Boston, Henry Ford Health System with West Bloomfield Center in Detroit, Kaiser Permanente Northern California at Redwood City, San Jose, Roseville and Martinez, the University of Colorado in Denver, Mayo Clinic in Rochester, OHSU in Portland, Stanford University in Redwood City, Virginia iSpine Physicians in Richmond and the VA Medical Center in Dallas. Due to very low recruitment we closed the site at Harborview Medical Center in Seattle. To date, we have screened 1936 patients. Of those screened, 405 (21%) were eligible and 362/405 (89%) were randomized: 117 in Detroit, 61 in Northern California, 117 in Boston, 21 in Denver, 4 in Seattle, 11 in Rochester, 5 in Portland, 14 at Stanford, 2 in Richmond and 10 in Dallas. The follow-up rate at 6-weeks, which is our primary endpoint, is 98%. We are on track to meet our recruitment goal and project that we will reach the target enrollment of 400 by late spring 2013. The BOLD Registry: We reached the recruitment goal of 5000 subjects. We closed recruitment at two sites: Kaiser Permanente Northern California and Harvard Vanguard Medical Associates. We continue recruiting subjects at Henry Ford Health System in order to enroll our target number of minority subjects. We are planning to close recruitment at Henry Ford at the end of March.To date, we have screened 13204 patients and enrolled 5244 subjects. The follow-up rate is 89% at 3-months and 85% at 12 months. We are exploring the possibility of additional funding in order to complete the 12 month follow-ups for all subjects at Henry Ford and to extend the follow-ups for all registry subjects to five years. On March 13, we submitted a grant application to PCORI "Comparing Engagement Techniques for Incorporating Patient Input in Research Prioritization". |
| Jobs Created |
31.36 |
| Description of Jobs Created |
ASST PROFESSOR WITHOUT TENURE-Requires a demonstration of teaching and research ability beyond that ordinarily required of an instructor. Faculty members WOT are funded by a variety of sources with a focus on research activities. BUDGET/FISCAL UNIT SUPERVISOR-Supervise others in the development, implementation and maintenance of complex financial information systems and processes. CLINICAL PROFESSOR-SALARIED-Clinical faculty make substantial contributions to University programs with the faculty in preparing and assisting with the instruction of students in practicum settings. PREDOCTORAL RESEARCH ASSOCIATE 1-Engage in research on sponsored projects under general supv of faculty/research staff. May include independent research under the guidance of a faculty member. PREDOCTORAL RESEARCH ASSOCIATE 2-Engage in research on sponsored projects under general supv of faculty/research staff. PROFESSOR WITHOUT TENURE-Requires outstanding, mature scholarship and research as evaluated in terms of national or international recognition, and evidenced by accomplishments in full range of academic responsibilities. PROFESSOR-Requires outstanding, mature scholarship and research as evaluated in terms of national or international recognition, and evidenced by accomplishments in full range of academic responsibilities. Professsor PROJECT APPOINTMENT - OVERTIME EXEMPT-Perform assigned professional work. Research Assistant Research Associate RESEARCH ASSISTANT PROFESSOR-Requires a demonstration of teaching and research ability beyond that ordinarily required of an instructor. RESEARCH COORDINATOR-Provide coordination for significant multi-funded or multi-site research project(s). Participate in development of research designs; methods and strategies for data management and collection. RESEARCH SCIENTIST/ENGINEER 4-Make ind. judgments re: appl of scientific techniques/procedures. Conduct work req substantial adaptation/modification. Devise new approaches and utilize complex principles, theories and concepts. RESEARCH SCIENTIST/ENGINEER-SENIOR-Independently apply advanced scope of scientific knowledge and principles in planning and executing lab research. Work involves extremely complex problems of diverse scope. RESEARCH STUDY COORDINATOR 1-Coordinate the operations of clinical, biomedical and/or behavioral research studies involving human subjects. SENIOR COMPUTER SPECIALIST-Provide technical expertise in all aspects of computing technology. Requires broad knowledge of hardware and software technologies. Develop web and database applications and/or application software. SENIOR FELLOW-Works under the direction of PI for the benefit of the research programs, the departments educational program, and their own professional growth. In most most fields marked by a doctoral degree. The Principal Investigator provides overall leadership for the study, helps to screen patients, and administers injections. The Research Coordinator manages the operations of the study and interaction with the primary study location; helps screen, consent and track patients; assists with billing; and ensures study compliance. The University of Colorado Denver Fellow assists with randomization and injection protocols as well as blood draws. The Research Assistant assists with screening and consenting and conducts on follow up procedures as outlined in the protocol. The Student Research Assistant assists with screening and consenting and conducts on follow up procedures as outlined in the protocol. Clinical Assistant Professor, Accociate Professor and Social Science Research Assistant, were retained to carry out the scope of work for this project. Research Coordinator-Responsible for conducting clinical trials and assisting with research projects using good clinical practice under the supervision of a Principal investigator (PI). The Research Coordinators primary responsibility is the protection of human subjects while carrying forward the research goals of a project. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-1701 |
| Award Information |
| Award Date |
09/28/2010 |
| Award Number |
1R01HS01922201 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$9,887,064 |
| Funds Invoiced/Received |
$7,923,023 |
| Expenditure Amount |
$7,967,203 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
14 |
| Sub-award Amounts to Organizations |
$6,569,411 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
1 |
| Amount of Sub-awards less than $25,000/award |
$20,580 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$34,040 |
| Number of payments to vendors less than $25,000/award |
39 |
| Total Amount of payments to vendors less than $25,000/award |
$41,401 |
Sub-award 710429z - AXIO RESEARCH ACQUISITION COMPANY, LLC
| Sub-Award Amount |
$20,580 |
| Sub-Award Date |
03/04/2011 |
| Sub-Awards Disbursed |
$16,110.00 |
| Project Location - City |
SEATTLE |
| Project Location - State |
WA |
| Project Location - Zip Code |
98121-1254 |
| Project Location - Congressional District |
07 |
| Sub-Recipient DUNS Number |
172217635
|
| Sub-Recipient Address |
2601 4TH AVE STE 200 |
| Sub-Recipient City |
SEATTLE |
| Sub-Recipient State |
Washington |
| Sub-Recipient Zip Code |
98121-1254 |
| Sub-Recipient Congressional District |
07 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 704350Z - BRIGHAM AND WOMEN'S HOSPITAL, INC., THE
| Sub-Award Amount |
$531,034 |
| Sub-Award Date |
12/20/2010 |
| Sub-Awards Disbursed |
$513,782.89 |
| Project Location - City |
Boston |
| Project Location - State |
MA |
| Project Location - Zip Code |
02115-6110 |
| Project Location - Congressional District |
07 |
| Sub-Recipient DUNS Number |
030811269
|
| Sub-Recipient Address |
75 FRANCIS ST |
| Sub-Recipient City |
BOSTON |
| Sub-Recipient State |
Massachusetts |
| Sub-Recipient Zip Code |
02115-6110 |
| Sub-Recipient Congressional District |
07 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 726693Z - BRIGHAM AND WOMEN'S HOSPITAL, INC., THE
| Sub-Award Amount |
$1,299,128 |
| Sub-Award Date |
12/02/2011 |
| Sub-Awards Disbursed |
$1,103,255.00 |
| Project Location - City |
Boston |
| Project Location - State |
MA |
| Project Location - Zip Code |
02115-6110 |
| Project Location - Congressional District |
07 |
| Sub-Recipient DUNS Number |
030811269
|
| Sub-Recipient Address |
75 FRANCIS ST |
| Sub-Recipient City |
BOSTON |
| Sub-Recipient State |
Massachusetts |
| Sub-Recipient Zip Code |
02115-6110 |
| Sub-Recipient Congressional District |
07 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 741332Z - DALLAS VA RESEARCH CORPORATION
| Sub-Award Amount |
$86,230 |
| Sub-Award Date |
11/01/2012 |
| Sub-Awards Disbursed |
$42,715.00 |
| Project Location - City |
DALLAS |
| Project Location - State |
TX |
| Project Location - Zip Code |
75216-7167 |
| Project Location - Congressional District |
30 |
| Sub-Recipient DUNS Number |
926938143
|
| Sub-Recipient Address |
4500 S LANCASTER BLDG 43 RM 140 |
| Sub-Recipient City |
DALLAS |
| Sub-Recipient State |
Texas |
| Sub-Recipient Zip Code |
75216-7167 |
| Sub-Recipient Congressional District |
30 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 704359Z - HENRY FORD HEALTH SYSTEM
| Sub-Award Amount |
$843,588 |
| Sub-Award Date |
11/16/2010 |
| Sub-Awards Disbursed |
$731,039.14 |
| Project Location - City |
Detroit |
| Project Location - State |
MI |
| Project Location - Zip Code |
48202-2689 |
| Project Location - Congressional District |
13 |
| Sub-Recipient DUNS Number |
073134603
|
| Sub-Recipient Address |
1 FORD PLACE |
| Sub-Recipient City |
DETROIT |
| Sub-Recipient State |
Michigan |
| Sub-Recipient Zip Code |
48202-3450 |
| Sub-Recipient Congressional District |
13 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 726885Z - HENRY FORD HEALTH SYSTEM
| Sub-Award Amount |
$987,000 |
| Sub-Award Date |
01/23/2012 |
| Sub-Awards Disbursed |
$712,803.00 |
| Project Location - City |
DETROIT |
| Project Location - State |
MI |
| Project Location - Zip Code |
48202-3450 |
| Project Location - Congressional District |
13 |
| Sub-Recipient DUNS Number |
073134603
|
| Sub-Recipient Address |
1 FORD PLACE |
| Sub-Recipient City |
DETROIT |
| Sub-Recipient State |
Michigan |
| Sub-Recipient Zip Code |
48202-3450 |
| Sub-Recipient Congressional District |
13 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 726710Z - KAISER FOUNDATION HOSPITALS
| Sub-Award Amount |
$1,352,940 |
| Sub-Award Date |
12/01/2011 |
| Sub-Awards Disbursed |
$1,167,020.00 |
| Project Location - City |
OAKLAND |
| Project Location - State |
CA |
| Project Location - Zip Code |
94612-3433 |
| Project Location - Congressional District |
13 |
| Sub-Recipient DUNS Number |
150829349
|
| Sub-Recipient Address |
1800 HARRISON ST FL 16 |
| Sub-Recipient City |
OAKLAND |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
94612-3429 |
| Sub-Recipient Congressional District |
13 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 704360Z - KAISER FOUNDATION HOSPITALS
| Sub-Award Amount |
$871,474 |
| Sub-Award Date |
12/22/2010 |
| Sub-Awards Disbursed |
$764,619.00 |
| Project Location - City |
OAKLAND |
| Project Location - State |
CA |
| Project Location - Zip Code |
94612-3433 |
| Project Location - Congressional District |
13 |
| Sub-Recipient DUNS Number |
150829349
|
| Sub-Recipient Address |
1800 HARRISON ST FL 16 |
| Sub-Recipient City |
OAKLAND |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
94612-3429 |
| Sub-Recipient Congressional District |
13 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 737951Z - LELAND STANFORD JUNIOR UNIVERSITY, THE
| Sub-Award Amount |
$72,540 |
| Sub-Award Date |
06/05/2012 |
| Sub-Awards Disbursed |
$46,025.00 |
| Project Location - City |
Stanford |
| Project Location - State |
CA |
| Project Location - Zip Code |
94305-4100 |
| Project Location - Congressional District |
18 |
| Sub-Recipient DUNS Number |
009214214
|
| Sub-Recipient Address |
450 SERRA MALL |
| Sub-Recipient City |
STANFORD |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
94305-2004 |
| Sub-Recipient Congressional District |
18 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 728420Z - MAYO CLINIC
| Sub-Award Amount |
$104,205 |
| Sub-Award Date |
04/09/2012 |
| Sub-Awards Disbursed |
$47,220.00 |
| Project Location - City |
Rochester |
| Project Location - State |
MN |
| Project Location - Zip Code |
55905-0001 |
| Project Location - Congressional District |
01 |
| Sub-Recipient DUNS Number |
006471700
|
| Sub-Recipient Address |
200 1ST ST SW |
| Sub-Recipient City |
ROCHESTER |
| Sub-Recipient State |
Minnesota |
| Sub-Recipient Zip Code |
55905-0002 |
| Sub-Recipient Congressional District |
01 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 737976Z - OREGON HEALTH & SCIENCE UNIVERSITY
| Sub-Award Amount |
$47,050 |
| Sub-Award Date |
05/02/2012 |
| Sub-Awards Disbursed |
$42,767.00 |
| Project Location - City |
Portland |
| Project Location - State |
OR |
| Project Location - Zip Code |
97239-3098 |
| Project Location - Congressional District |
03 |
| Sub-Recipient DUNS Number |
096997515
|
| Sub-Recipient Address |
3181 SW SAM JACKSON PARK RD |
| Sub-Recipient City |
PORTLAND |
| Sub-Recipient State |
Oregon |
| Sub-Recipient Zip Code |
97201-3011 |
| Sub-Recipient Congressional District |
03 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 704344Z - OREGON HEALTH & SCIENCE UNIVERSITY
| Sub-Award Amount |
$182,207 |
| Sub-Award Date |
11/04/2010 |
| Sub-Awards Disbursed |
$140,326.74 |
| Project Location - City |
PORTLAND |
| Project Location - State |
OR |
| Project Location - Zip Code |
97239-3098 |
| Project Location - Congressional District |
03 |
| Sub-Recipient DUNS Number |
096997515
|
| Sub-Recipient Address |
3181 SW SAM JACKSON PARK RD |
| Sub-Recipient City |
PORTLAND |
| Sub-Recipient State |
Oregon |
| Sub-Recipient Zip Code |
97201-3011 |
| Sub-Recipient Congressional District |
03 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 728421Z - REGENTS OF THE UNIVERSITY OF COLORADO, THE
| Sub-Award Amount |
$141,180 |
| Sub-Award Date |
02/17/2012 |
| Sub-Awards Disbursed |
$95,419.00 |
| Project Location - City |
AURORA |
| Project Location - State |
CO |
| Project Location - Zip Code |
80045-2505 |
| Project Location - Congressional District |
06 |
| Sub-Recipient DUNS Number |
041096314
|
| Sub-Recipient Address |
13001 E 17TH PL BLDG 500 W1126 |
| Sub-Recipient City |
AURORA |
| Sub-Recipient State |
Colorado |
| Sub-Recipient Zip Code |
80045-2505 |
| Sub-Recipient Congressional District |
06 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 739547Z - VIRGINIA I-SPINE PHYSICIANS, P.C.
| Sub-Award Amount |
$30,255 |
| Sub-Award Date |
08/22/2012 |
| Sub-Awards Disbursed |
$12,530.00 |
| Project Location - City |
RICHMOND |
| Project Location - State |
VA |
| Project Location - Zip Code |
23235-1944 |
| Project Location - Congressional District |
07 |
| Sub-Recipient DUNS Number |
078518493
|
| Sub-Recipient Address |
9020 STONY POINT PKWY STE 140 |
| Sub-Recipient City |
RICHMOND |
| Sub-Recipient State |
Virginia |
| Sub-Recipient Zip Code |
23235-1944 |
| Sub-Recipient Congressional District |
07 |
Required To Report Top 5
Highly Compensated Officials |
No |
Target Corporation - Award Number 1R01HS01922201 - Target Corporation
| Award Number |
1R01HS01922201 |
| Sub-Award Number |
704360Z |
| Vendor DUNS Number |
006961700 |
| Vendor HQ Zip Code + 4 |
55403-2542 |
| Vendor Name |
Target Corporation |
| Product and Service Description |
Acquisition of Target Corporation Gift Cards for participants. |
| Payment Amount |
$34,040 |
| Location Information |
| Latitude, Longitude |
47º 39' 17",
-122º 18' 7" |
| Congressional District |
07 |
| Address 1 |
4333 Brooklyn Avenue, NE |
| Address 2 |
|
| City |
SEATTLE |
| County |
King |
| State |
WA |
| Zip |
98195-0000 |
|
 |