YALE UNIVERSITY
The proposed longitudinal study is designed to examine reading development at critical points in its establishment (from ages 7.5-10.5) in nonimpaired (Nl) and reading disabled (RD) cohorts. Our previous cross sectional research has identified reading group differences in both functional neuroanatomical and behavioral trajectories; the proposed longitudinal study is aimed at gaining a better understanding of behavioral, neurobiological, and genetic etiological factors responsible for this observed divergence. We examine the hypothesis that the candidate etiological agent that might underlie variation in neurodevelopmental and behavioral trajectories is gamma-aminobutyric acid (GABA): research has shown that GABA plays a critical role in learning and memory. Accordingly, the proposed research will permit relating developmental changes in reading performance and functional neuroanatomy for reading (measured with fMRI) to GABA expression, measured with magnetic resonance spectroscopy (MRS) and genetic analyses, linking polymorphisms in the GABA family genes to GABA expression in the brain. Specifically, the research aims to: 1) Characterize concurrent relations among genetics, neurochemistry, functional neuroanatomy, and reading behavior at 2 important timepoints in reading development, 2) Investigate Nl and RD differences for each of these measures, 3) Examine subsequent developmental trajectories in Nl and RD cohorts, 4) Better characterize learning capacities and learning styles in these cohorts, 5) Develop dynamic brain/behavior phenotypes sensitive to genetic analyses, and 6) Contrast multi-level profiles and developmental trajectories in subgroups of RD.
| AWARD OVERVIEW |
| Award Number |
3R01HD048830-05S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$111,757 |
Project Location - City |
New Haven |
| Award Date |
07/30/2010 |
Project Location - State |
CT |
| Project Status |
Completed |
Project Location - Zip |
06520-8047
|
| Jobs Reported |
1.00 |
Congressional District |
03 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
YALE UNIVERSITY |
| Recipient DUNS Number |
043207562
|
| Recipient Address |
105 WALL ST |
| Recipient City |
NEW HAVEN |
| Recipient State |
Connecticut |
| Recipient Zip |
06511-6614 |
| Recipient Congressional District |
03 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Neurobiological Foundations in Reading (dis) Ability |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
The ARRA grant yoked with the R01 entitled ?Neurobiological Foundations of Reading and Learning in Reading Disability? (Kenneth Pugh, PI) is a one-year project examining MRI and fMRI data from a longitudinal tracking study designed to examine reading development at three critical points (Time 1 = 7.5 years, Time 2 = 8.5 years, and Time 3 = 9.5 years) in non-impaired (NI) and reading disabled (RD) individuals. The ARRA funded project adds a new focus on intensive analysis of structural MR data acquired during fMRI scanning sessions at Time 1 and Time 3. To work on this we hired a Post-doctoral Associate (Dr. Peter Molfese), under supervision of Dr. Hemant Tagare and Dr. Ken Pugh, is examining structural MRI data and linking it with both fMRI and cognitive measures to identify those brain/behavior patterns that discriminate NI and RD cohorts at different time points. To date, automatic volumetric calculations for 362 participants have been performed using Freesurfer 5.1. Freesurfer allows for cortical parcellation based on gyral and sulcal structures, or the calculation of volume within structures of the brain. Data were next exported to the SAS statistical software for analyses. Individuals who had brain regions with volumes identified as statistical outliers (greater than 2 standard deviations above the mean), were rechecked. At this point, enough data has been processed from both the first and third time points to begin longitudinal analyses of anatomical brain data. To date, statistical analyses have begun to investigate how changes in behavioral measures collected at the first and third time point corresponding to changes in anatomical brain structure volume and cortical thickness. We have also begun preparing data for final analyses using subgroups within our sample comparing children with speech sound disorders and children who developed the ability to speak later than typically developing children. This is the final quarterly report. |
| Jobs Created |
1.00 |
| Description of Jobs Created |
Postdoctoral Associate |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0840 |
| Award Information |
| Award Date |
07/30/2010 |
| Award Number |
3R01HD048830-05S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$111,757 |
| Funds Invoiced/Received |
$108,965 |
| Expenditure Amount |
$108,965 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
4 |
| Total Amount of payments to vendors less than $25,000/award |
$6,909 |
| Location Information |
| Latitude, Longitude |
41º 18' 35",
-72º 55' 41" |
| Congressional District |
03 |
| Address 1 |
P.O. Box 208047 |
| Address 2 |
|
| City |
New Haven |
| County |
New Haven |
| State |
CT |
| Zip |
06520-8047 |
|
 |