UNIVERSITY OF MASSACHUSETTS
"This award was for a 3-year Director's opportunity award entitled ""Translating Dosage Compensation to Trisomy"". Our lab has long studied inactivation of one X-chromosome which provides for equal dosage of genes between males and females. While basic science aspects of X-inactivation are widely studied as an important model for developmental control of gene regulation, the Lawrence lab is also interested in the clinical relevance of this for understanding genetic disease. Having the proper dosage of genes can be as important as having the correct sequence of genes, thus understanding the dosage compensation mechanism of the X-chromosome can have relevance to human conditions in which chromosomal ""dosage"" is abnormal. The most common and clinically important example of this is trisomy 21 which causes Down Syndrome. Currently there is little therapeutic option for individuals who carry defects of chromosomal dosage, and our goal is to extend insights from normal human X-chromosome inactivation in directions that provide better understanding of chromosomal dosage disorders and may eventually lead to therapies. Since X-chromosome dosage compensation occurs in very early embryonic cells, this project focuses on studying abnormalities of chromosomal dosage in human and mouse iPS cells. This approach uses skin or other somatic cells that are induced to have properties of pluripotent stem cells, avoiding the ethical issues raised by use of human embryonic stem cells."
Choose a quarter and click "Go."
| AWARD OVERVIEW |
| Award Number |
1RC4GM096400-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$2,507,052 |
Project Location - City |
Worcester |
| Award Date |
09/30/2010 |
Project Location - State |
MA |
| Project Status |
More than 50% Completed |
Project Location - Zip |
01655-0002
|
| Jobs Reported |
7.22 |
Congressional District |
02 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF MASSACHUSETTS |
| Recipient DUNS Number |
603847393
|
| Recipient Address |
55 LAKE AVE N |
| Recipient City |
WORCESTER |
| Recipient State |
Massachusetts |
| Recipient Zip |
01655-0002 |
| Recipient Congressional District |
02 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
ARRA: Translating Dosage Compensation to Trisomy |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
"As promised in the last quarterly report, we submitted a second round of revision (by invitation) for a manuscript that will show we accomplished the top priority of this project, submitted to one of the top biomedical journals. This manuscript demonstrates success at the central ""high risk, high innovation"" goal of this project, and represents a major advance in translating understanding of dosage compensation for the X chromosome to problems of abnormal dosage compensation, such as in Down Syndrome. Work for revision was completed and the manuscript resubmitted one month ago, so we hope to hear soon. We are also making progress on extending this project to the mouse model system, and have generated key reagents for this purpose. However, we needed to repeat the targeting work because the first transgenesis was not successful, for technical reasons related to transgene expression as well as accuracy of targeting. We are constructing new transgenes designed for two different mouse models." |
| Jobs Created |
7.22 |
| Description of Jobs Created |
5 Professors, Instructor, 2 Research Associates, Research Lab Tech, 3 Graduate Students |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0852 |
| Award Information |
| Award Date |
09/30/2010 |
| Award Number |
1RC4GM096400-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$2,507,052 |
| Funds Invoiced/Received |
$1,920,708 |
| Expenditure Amount |
$1,965,126 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$25,500 |
| Number of payments to vendors less than $25,000/award |
376 |
| Total Amount of payments to vendors less than $25,000/award |
$224,536 |
Bio-RAD Laboratories, Inc - Award Number 1RC4GM096400-01 - Bio-RAD Laboratories, Inc
| Award Number |
1RC4GM096400-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
884513334 |
| Vendor HQ Zip Code + 4 |
94547-1803 |
| Vendor Name |
Bio-RAD Laboratories, Inc |
| Product and Service Description |
Research/Educational Equipment |
| Payment Amount |
$25,500 |
| Location Information |
| Latitude, Longitude |
42º 16' 43",
-71º 45' 32" |
| Congressional District |
02 |
| Address 1 |
55 Lake Avenue North |
| Address 2 |
|
| City |
Worcester |
| County |
Worcester |
| State |
MA |
| Zip |
01655-0002 |
|
 |