Contracts - AWARD SUMMARY
BROAD INSTITUTE, INC., THE
This contract was awarded on September 24, 2010. We are providing
second generation sequencing of tumor samples across numerous tumor
types in support of The Cancer Genome Atlas (TCGA) project. In
additional validation sequencing on mutations is also performed.
Generated data will be provided to the Sequence Read Archive hosted at
the National Center for Biotechnology Information. During the base
period will be sequencing approximately 49,800 Gb of data. This
data will be shared with The Cancer Genome Atlas community via numerous
avenues, for example, conference calls and Steering Committee meetings.
In addition, strategic planning continues to discuss the project
requirements within our organization, NCI and TCGA community.
Choose a quarter and click "Go."
| AWARD OVERVIEW |
| Award Number |
HHSN261201000055C |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$30,965,067 |
Project Location - City |
Cambridge |
| Award Date |
09/24/2010 |
Project Location - State |
MA |
| Project Status |
More than 50% Completed |
Project Location - Zip |
02142-1401
|
| Jobs Reported |
13.77 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Contracts)
| Recipient Information (Contracts) |
|
Recipient Name
|
BROAD INSTITUTE, INC., THE |
| Recipient DUNS Number |
623544785
|
| Recipient Address |
7 CAMBRIDGE CTR |
| Recipient City |
CAMBRIDGE |
| Recipient State |
Massachusetts |
| Recipient Zip |
02142-1401 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Federal Contract |
| Project Status |
More than 50% Completed |
| Final Project Report Submitted |
No |
| Project Activities Description |
Testing Laboratories |
| Quarterly Activities/Project Description |
During the past quarter, we have received 274 new cases across 8 tumor types to perform next generation sequencing and somatic alteration discovery. We are in the process of exome sequencing 291 TCGA cases. Full coverage exome sequencing data has now been completed for 2952 ARRA designated TCGA patient specimens (excluding Ovarian & GBM). This number represents a total of 580 cases completed in this reporting period fully clearing the backlog of samples that had accumulated over the past quarter. We have also implemented a new automated mutation calling and MAF/VCF submission process that includes a filtering pipeline to accurately identify and remove ‘8-Oxo-G’ artifacts present in a subset of our data. This new pipeline is advantageous in that it both improves the quality of the mutation calls being submitted as well as automates a previously manual process for data submission.
We continue to invest in deep coverage whole genome sequencing data for the TCGA lung adenocarcinoma, lung squamous cell carcinoma, renal clear cell carcinoma, and head and neck squamous cell carcinoma projects and have completed a total of 112 whole genomes (56 cases) for these four sub-projects. Additional whole genome sequencing was recently initiated in the glioblastoma multiforme as well as the lung adenocarcinoma project and we anticipate that 71 additional cases will be available by the end of the year. These new whole genomes represent a significant increase the in the scale of whole genome sequencing previously attempted for TCGA and expect this trend to continue as working groups nominate additional samples for whole genome analysis over the next year.
Our raw data submission pipeline is now fully compliant with the new sequence data hosting center cgHUB and all previously self-hosted data is now live and accessible to users.
|
| Jobs Created |
13.77 |
| Description of Jobs Created |
Director of Genome Sequencing and Analysis Program and Seq Platform, Dir Sequencing Informatics Development, Institute Director, Mgr Medical and Sequencing Informatics, Computational Biologist, Software Engineer III, Project Coordinator, Mgr Cancer Genomics Projects, Sr. Software Engineer I, Genomics Platform Lab Technicians. |
Purchaser Information
(Contracts)
| Purchaser Information |
| Contracting Office ID |
261 |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0850 |
| Award Information |
| Award Date |
09/24/2010 |
| Award Number |
HHSN261201000055C |
| Order Number |
|
| Award Type |
Contracts |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$30,965,067 |
| Funds Invoiced/Received |
$26,516,676 |
| Expenditure Amount |
$0 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Contracts)
| Product or Service Information |
| Primary Activity Code |
541380 |
| Activity Description |
Testing Laboratories |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
0 |
| Total Amount of payments to vendors greater than $25,000/award |
$0 |
| Number of payments to vendors less than $25,000/award |
0 |
| Total Amount of payments to vendors less than $25,000/award |
$0 |
| Location Information |
| Latitude, Longitude |
42º 21' 50",
-71º 5' 17" |
| Congressional District |
07 |
| Address 1 |
7 Cambridge Center |
| Address 2 |
|
| City |
Cambridge |
| County |
Middlesex |
| State |
MA |
| Zip |
02142-1401 |
|
 |