WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
This supplemental proposal is designed to enhance and fully develop the capabilities of the WVU Genomics Core Facility to support translational research studies by both clinical and basic science investigators at West Virginia University. The proposal builds on existing equipment and technologies to rapidly advance research initiatives in gene discovery for areas of neurodegenerative diseases and behavioral disorders. More broadly, the core facility will serve the research needs of clinicians and basic scientists across the spectrum on research endeavors, including cardiovascular, pulmonary, and cancer biology. The funds requested will support a full-time, faculty-level bioinformatics expert, who will serve as director of the core facility, a junior scientist seeking an alternative career path, who will serve as the assistant director, and a graduate-level student computer programmer, who will help to facilitate microarray data analysis, storage, and retrieval and to implement advancements in microarray experimental analysis. Two of these positions require new recruitment, offering new employment openings, while the other position seeks to retain a skilled investigator in an alternative scientific career path as core facility assistant director. Requested funds will also support initial purchase of reagents for RNA isolation and processing, microarray probe preparation and hybridization, and microarray analysis. Remaining resources will be spent in an effort to facilitate cooperation and collaboration between the Genomics Core Facilities at Marshall University and West Virginia University. Support for the WVU Genomics Core Facility will accelerate its development to a full-service, fully operational core facility to advance gene discovery and gene expressions research efforts at WVU.