Grants - AWARD SUMMARY


UNIVERSITY OF MASSACHUSETTS


The role of microRNAs in the Erythropoietic Stress Response. In aim 1, we will Investigate whether candidate erythroid miRNAs are differentially expressed in erythroid progenitors of mouse models of erythropoietic stress. In aim 2, we wukk investigate whether these candidate miRNAs functionally target erythroid apoptotic regulators . In aim 3, we will use deep sequencing of small RNA libraries derived from erythroid progenitors, to obtain the miRNA expression profile during the stress response, and to discover novel miRNAs that are differentially expressed in erythropoietic stress

Clarification of Codes

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AWARD OVERVIEW

AWARD OVERVIEW
Award Number 3R01HL084168-04S1 Funding Agency Department of Health and Human Services
Total Award Amount $170,284 Project Location - City Worcester
Award Date 08/01/2009 Project Location - State MA
Project Status Completed Project Location - Zip 01655-0002
Jobs Reported 0.70 Congressional District 03
Project Location - Country US

Recipient Information (Grants)

Recipient Information (Grants)
Recipient Name UNIVERSITY OF MASSACHUSETTS
Recipient DUNS Number 603847393
Recipient Address 55 LAKE AVE N
Recipient City WORCESTER
Recipient State Massachusetts
Recipient Zip 01655-0002
Recipient Congressional District 03
Recipient Country USA
Required to Report Top 5
Highly Compensated Officials		 No

Projects and Jobs Information

Projects and Jobs Information
Project Title Molecular Analysis of the Erythropoietic Stress Response in Vivo
Project Status Completed
Final Project Report Submitted Yes
Project Activities Description Medical Research, General/Other
Quarterly Activities/Project Description We identified a number of microRNAs that are regulating the response of several proteins in the TGF-beta pathway. Data analysis combining our gene expression microarray and microRNA expression data showed that a group of microRNAs may be involed in modulating the response of erythroid progenitors to TGFbeta. We began to examine cell-surface expression of the TGF-beta receptors on erythroid progenitors during stress erythropoiesis in the mouse. The final invoicing for the project will be complete in the next couple weeks.
Jobs Created 0.70
Description of Jobs Created Research Associate


Purchaser Information (Grants)

Purchaser Information
Contracting Office ID Not Reported
Contracting Office Name Not Available
Contracting Office Region Not Available
TAS Major Program 75-0871

Award Information

Award Information
Award Date 08/01/2009
Award Number 3R01HL084168-04S1
Order Number
Award Type Grants
Funding Agency ID 75
Funding Agency Name Department of Health and Human Services
Funding Office Name Not Available
Awarding Agency ID 75
Awarding Agency Name Department of Health and Human Services
Amount of Award $170,284
Funds Invoiced/Received $170,281
Expenditure Amount $170,284
Infrastructure Expenditure Amount $0
Infrastructure Purpose and Rationale Not Reported
Infrastructure Point of Contact Name Not Reported
Infrastructure Point of Contact Email Not Reported
Infrastructure Point of Contact Phone Not Reported
Infrastructure Point of Contact Address Not Reported
Infrastructure Point of Contact City Not Reported
Infrastructure Point of Contact State Not Reported
Infrastructure Point of Contact Zip Not Reported

Product or Service Information (Grants)

Product or Service Information
Primary Activity Code H01
Activity Description Medical Research, General/Other

Sub-Awards Information

Sub-Awards Information
Sub-awards to Organizations 0
Sub-award Amounts to Organizations $0
Sub-Awards to Individuals 0
Sub-Award Amounts to Individuals $0
Number of Sub-awards less than $25,000/award 0
Amount of Sub-awards less than $25,000/award $0
Number of payments to vendors greater than $25,000 0
Total Amount of payments to vendors greater than $25,000/award $0
Number of payments to vendors less than $25,000/award 152
Total Amount of payments to vendors less than $25,000/award $24,108







Project Location Detail

Location Information
Latitude, Longitude 42º 16' 39", -71º 45' 33"
Congressional District 03
Address 1 55 Lake Avenue North
Address 2
City Worcester
County Worcester
State MA
Zip 01655-0002
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