HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M
The goal of this study is to better understand the body's immune response to worms that invade human tissues. Results may lead to better approaches for developing vaccines against worms and to new concepts for how to treat autoimmune and allergic diseases.
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| AWARD OVERVIEW |
| Award Number |
1R01AI076522-01A2 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$765,000 |
Project Location - City |
Bethesda |
| Award Date |
07/22/2009 |
Project Location - State |
MD |
| Project Status |
Completed |
Project Location - Zip |
20814-4712
|
| Jobs Reported |
0.00 |
Congressional District |
08 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY M |
| Recipient DUNS Number |
144676566
|
| Recipient Address |
6720-A ROCKLEDGE DR STE 100 |
| Recipient City |
BETHESDA |
| Recipient State |
Maryland |
| Recipient Zip |
20817-1834 |
| Recipient Congressional District |
08 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Role of basophils and IgE in the immune response to Litomosoides |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
This grant is now complete. Results of the work done is as follows. 1) We showed that basophils amplify arms of the immune system that drive allergy and the host response to parasitic diseases. This work was published in the Journal of Immunology. 2) We demonstrated that chronic worm infections suppress the ability of basophils, one of the important cell types involved in allergic reactions, to respond to activating signals. These findings were published in another paper in the Journal of Immunology. 3) We showed that suppression of basophils also occurs in humans infected with worms. 4) Additionally, we optimized techniques to assess activation of mast cells, the other major effector cell in allergic responses. This work was published in the Journal of Immunological Methods. 5) Finally, we demonstrated that a vaccine dependent on allergic type responses against helminth infections maintains efficacy even in the setting of repeated infectious challenges. This was published in the journal Vaccine. Significance: The findings that basophils play a key role amplifying allergic responses demonstrates that these cells have important physiologic functions in addition to acting as effector cells of allergy. Since we have shown that basophils are key to enhancing IgE production, these findings suggest that targeting basophils may be a reasonable approach for treating IgE-mediated diseases such as allergy. The finding that chronic helminth infection suppresses basophil function in both mice and humans provides a potential explanation for how helminth infections protect against allergic disease. This work may lead to novel therapies for treatment of allergic disease. The demonstration that vaccines which induce type 2 immune responses maintain efficacy despite repeated infectious challenges suggests that such vaccines, if safe and effective, would likely maintain their efficacy in the real-world setting of repeated infectious challenges. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
N/A |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0900 |
| Award Information |
| Award Date |
07/22/2009 |
| Award Number |
1R01AI076522-01A2 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$765,000 |
| Funds Invoiced/Received |
$763,573 |
| Expenditure Amount |
$763,573 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
1 |
| Total Amount of payments to vendors greater than $25,000/award |
$26,544 |
| Number of payments to vendors less than $25,000/award |
332 |
| Total Amount of payments to vendors less than $25,000/award |
$220,238 |
Trs Labs Inc - Award Number 1R01AI076522-01A2 - Trs Labs Inc
| Award Number |
1R01AI076522-01A2 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
199543034 |
| Vendor HQ Zip Code + 4 |
30605-2739 |
| Vendor Name |
Trs Labs Inc |
| Product and Service Description |
Adult L. sigmodonits-JIRDS; L. sigmodonits - JIRDS |
| Payment Amount |
$26,544 |
| Location Information |
| Latitude, Longitude |
38º 59' 57",
-77º 5' 9" |
| Congressional District |
08 |
| Address 1 |
4301 Jones Bridge Rd |
| Address 2 |
|
| City |
Bethesda |
| County |
Montgomery |
| State |
MD |
| Zip |
20814-4712 |
|
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