WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
The original aims of DK64668 were to interrogate the basic mechanistic underpinnings of microvascular dysfunction that develop in the OZR model of the metabolis syndrome and to determine how these alterations contribute to a impaired state of skeletal muscle perfusion: demand matching. The original aims were: 1)To fully elucidate the temporal development of the individual pathologies comprising Syndrome X in OZR and to determine specific alterations to skeletal muscle perfusion and to skeletal muscle microcirculatory structure/function which evolve with progression of the systemic pathologies. 2)To determine the ability of pharmacological/dietary treatment of the primary pathologies comprising Syndrome X in OZR to prevent the development of imparments to skeletal muscle perfusion and vicrovascular structure/function. 3)To determine if chronic exercise can reverse (in adult rats) or prevent (in young rats) the development of negative alterations to skeletal muscle perfusion and microcirculatory structure/funcion in OZR. Essentially, the funds provided by this administrative supplement would allow us to retain Ms. James (at 100% FTE on the project) and continue acquiring obese zucker rats (a very costly animal) at a rate which provides for excellent productivity.