UNIVERSITY OF WASHINGTON
Twin studies have provided insights into multiple disease and developmental endpoints. Because their genetic and environmental similarities are easily understood, twins can elucidate the contributions of genetic and environmental factors to illness and health. Twin studies have also integrated molecular methods to examine gene-environment interactions and epigenetics. Although many countries claim to have registries, only those in Scandinavia are large population-based twin registries. The few American twin registries that exist have shortcomings that hamper the advancement of research in the US. The two registries that approximate the population from which they were drawn, the WWII Veteran and Vietnam Era Twin Registries, have only male twins restricted by age and lack of racial and ethnic diversity. The state-based registries, for example the Mid-Atlantic and Minnesota Twin Registries, have been constructed by identifying twins from birth records which are then linked to driver license information. However, these registries disproportionately miss female twins who have married and taken on their husband's surname. They also include participants who may not be representative of the reference population. The University of Washington Twin Registry (UWTR) was established to study the genetic and non-genetic factors that affect health. The Registry is an ongoing collection of twins identified from the State of Washington Department of Licensing. Unique to Washington, the Department of Licensing asks every applicant if s/he is a twin to avoid issuing duplicate license identification numbers to twins. After obtaining relevant permissions, we began collecting the necessary information to construct the Registry. Currently, ~3,000 twin pairs are enrolled in the Registry and 280 twin pairs have participated in the sample and data repository. This application is to significantly expand the UWTR in order to fully establish this unique resource and accelerate the pace of research in understanding and treating multiple disease and developmental endpoints.
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| AWARD OVERVIEW |
| Award Number |
1RC2HL103416-01 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$7,648,906 |
Project Location - City |
SEATTLE |
| Award Date |
09/29/2009 |
Project Location - State |
WA |
| Project Status |
Completed |
Project Location - Zip |
98195-0000
|
| Jobs Reported |
0.00 |
Congressional District |
07 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
UNIVERSITY OF WASHINGTON |
| Recipient DUNS Number |
605799469
|
| Recipient Address |
4333 BROOKLYN AVE NE |
| Recipient City |
SEATTLE |
| Recipient State |
Washington |
| Recipient Zip |
98195-0001 |
| Recipient Congressional District |
07 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Building a Unique Resource: A National, Community-based Twin Repository |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
"Start-up Activities": Washington State Vital Statistics data linking is underway and should be completed shortly. "Milestone 1: Twin Recruitment": Twin enrollment at the end of the grant period is 7,205 pairs. With the infrastructure made possible by this award, recruitment will continue and we expect to enroll 100-200 pairs per month for the foreseeable future. Collection of DNA sample kits and phenotyping surveys for "Milestone 2: Twin Repository" was very successful. The repository has 8,868 DNA samples and 8,736 phenotyping questionnaires with a pairwise rate of approximately 80% for a total of 3,561 pairs with both DNA and survey data. For "Milestone 3: Environment & Health" we are continuing to geocode all new UWTR twins when they enroll in the Registry with the set of built and social environment exposure measures we have developed."Milestone 4: Multilevel Pain Study" has completed the in-person data gathering phase (200 pairs complete). Final sample processing is in progress and preliminary data analyses are starting.In terms of "Milestone 5: Data Sharing/Collaborations," 1 R01 will be reviewed on October 5, 1 R01 (>$500,000 direct costs) and 1 R21 are in preparation for October submission, with 3 R01 submissions in preparation for February 2013. Several manuscripts are under review and in preparation including a description of the Registry for a Special Issue of Twin Research and Human Genetics (submitted on September 17th). |
| Jobs Created |
0.00 |
| Description of Jobs Created |
No Jobs Were Created or Retained. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0871 |
| Award Information |
| Award Date |
09/29/2009 |
| Award Number |
1RC2HL103416-01 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$7,648,906 |
| Funds Invoiced/Received |
$7,648,906 |
| Expenditure Amount |
$7,648,906 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
Not Reported |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
Not Reported |
| Infrastructure Point of Contact City |
Not Reported |
| Infrastructure Point of Contact State |
Not Reported |
| Infrastructure Point of Contact Zip |
Not Reported |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
3 |
| Sub-award Amounts to Organizations |
$142,138 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
8 |
| Total Amount of payments to vendors greater than $25,000/award |
$372,427 |
| Number of payments to vendors less than $25,000/award |
442 |
| Total Amount of payments to vendors less than $25,000/award |
$864,404 |
Sub-award 703066Z - UNIVERSITY OF CALIFORNIA, SAN DIEGO
| Sub-Award Amount |
$51,807 |
| Sub-Award Date |
10/21/2010 |
| Sub-Awards Disbursed |
$49,019.96 |
| Project Location - City |
LA JOLLA |
| Project Location - State |
CA |
| Project Location - Zip Code |
92093-0934 |
| Project Location - Congressional District |
52 |
| Sub-Recipient DUNS Number |
804355790
|
| Sub-Recipient Address |
9500 GILMAN DR DEPT 621 |
| Sub-Recipient City |
LA JOLLA |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
92093-0621 |
| Sub-Recipient Congressional District |
52 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 676604Z - UNIVERSITY OF CALIFORNIA, SAN DIEGO
| Sub-Award Amount |
$52,023 |
| Sub-Award Date |
02/03/2010 |
| Sub-Awards Disbursed |
$49,029.73 |
| Project Location - City |
LA JOLLA |
| Project Location - State |
CA |
| Project Location - Zip Code |
92093-0934 |
| Project Location - Congressional District |
52 |
| Sub-Recipient DUNS Number |
804355790
|
| Sub-Recipient Address |
9500 GILMAN DR DEPT 621 |
| Sub-Recipient City |
LA JOLLA |
| Sub-Recipient State |
California |
| Sub-Recipient Zip Code |
92093-0621 |
| Sub-Recipient Congressional District |
52 |
Required To Report Top 5
Highly Compensated Officials |
No |
Sub-award 677011Z - UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
| Sub-Award Amount |
$38,308 |
| Sub-Award Date |
01/08/2010 |
| Sub-Awards Disbursed |
$24,986.62 |
| Project Location - City |
CHAPEL HILL |
| Project Location - State |
NC |
| Project Location - Zip Code |
27599-1350 |
| Project Location - Congressional District |
04 |
| Sub-Recipient DUNS Number |
608195277
|
| Sub-Recipient Address |
104 AIRPORT DR STE 2200 |
| Sub-Recipient City |
CHAPEL HILL |
| Sub-Recipient State |
North Carolina |
| Sub-Recipient Zip Code |
27599-5023 |
| Sub-Recipient Congressional District |
04 |
Required To Report Top 5
Highly Compensated Officials |
No |
DNA GENOTEK INC - Award Number 1RC2HL103416-01 - DNA GENOTEK INC
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
207983508 |
| Vendor HQ Zip Code + 4 |
-0000-0000 |
| Vendor Name |
DNA GENOTEK INC |
| Product and Service Description |
MAILING ACCESSORY - BIO SPECIMEN BAGS. QUANTITY: 2 |
| Payment Amount |
$39,675 |
DNA GENOTEK INC - Award Number 1RC2HL103416-01 - DNA GENOTEK INC
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
207983508 |
| Vendor HQ Zip Code + 4 |
0-00000 |
| Vendor Name |
DNA GENOTEK INC |
| Product and Service Description |
MAILING ACCESSORY - BIO SPECIMEN BAGS. QUANTITY: 1 |
| Payment Amount |
$39,775 |
DNA GENOTEK INC - Award Number 1RC2HL103416-01 - DNA GENOTEK INC
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
207983508 |
| Vendor HQ Zip Code + 4 |
0-000-0000 |
| Vendor Name |
DNA GENOTEK INC |
| Product and Service Description |
MAILING ACCESSORY - BIO SPECIMEN BAGS. QUANTITY: 1 |
| Payment Amount |
$39,875 |
DNA GENOTEK INC - Award Number 1RC2HL103416-01 - DNA GENOTEK INC
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
207983508 |
| Vendor HQ Zip Code + 4 |
-0000-0000 |
| Vendor Name |
DNA GENOTEK INC |
| Product and Service Description |
MAILING ACCESSORY - BIO SPECIMEN BAGS. QUANTITY: 2 |
| Payment Amount |
$40,005 |
DNA GENOTEK INC - Award Number 1RC2HL103416-01 - DNA GENOTEK INC
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
207983508 |
| Vendor HQ Zip Code + 4 |
-0000-0000 |
| Vendor Name |
DNA GENOTEK INC |
| Product and Service Description |
MAILING ACCESSORY - BIO SPECIMEN BAGS. QUANTITY: 2 |
| Payment Amount |
$53,610 |
Techline Communications, Inc. - Award Number 1RC2HL103416-01 - Techline Communications, Inc.
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
877048439 |
| Vendor HQ Zip Code + 4 |
98112-3642 |
| Vendor Name |
Techline Communications, Inc. |
| Product and Service Description |
6 ADDITIONAL TELEFORM VERIFIER LICENSES AND 1 YEAR |
| Payment Amount |
$33,704 |
Techline Communications, Inc. - Award Number 1RC2HL103416-01 - Techline Communications, Inc.
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
877048439 |
| Vendor HQ Zip Code + 4 |
98112-3642 |
| Vendor Name |
Techline Communications, Inc. |
| Product and Service Description |
UPGRADE TELEFORM V10.4 DESKTOP SN#403319 TO TELEFO |
| Payment Amount |
$36,108 |
Washington Department of Licensing - Award Number 1RC2HL103416-01 - Washington Department of Licensing
| Award Number |
1RC2HL103416-01 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
808883375 |
| Vendor HQ Zip Code + 4 |
98501 |
| Vendor Name |
Washington Department of Licensing |
| Product and Service Description |
DATA COLLECTION FEE FOR 01/01/10 - 12/31/11 FOR TH |
| Payment Amount |
$89,676 |
| Location Information |
| Latitude, Longitude |
47º 39' 17",
-122º 18' 7" |
| Congressional District |
07 |
| Address 1 |
4333 Brooklyn Avenue NE |
| Address 2 |
Box 359472 |
| City |
SEATTLE |
| County |
King |
| State |
WA |
| Zip |
98195-0000 |
|
 |