SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
The overall goal of the project is to characterize the structures and interactions of the BCL-2 family proteins, the principal regulators of the mitochondrion-dependent pathway for programmed cell death or apoptosis. Their opposing pro- or anti-apoptotic activities are exerted through a network of interactions with partners within and outside the BCL-2 family, both in the cytosol and in intracellular membranes. Their associations with each other and with mitochondrial membranes have particularly important consequences for mitochondrial physiology and for cell fate. Their functions are intimately related to a large number of major human diseases (cancer, neurodegeneration, AIDS, etc.). This Supplement supports studies that are currently in progress and that are expected to yield significant results in the next few months. It provides additional funded time and resources for a senior postdoc who is working on the project, and funds to purchase new laboratory equipment.
| AWARD OVERVIEW |
| Award Number |
3 R01 GM065374-04S1 |
Funding Agency |
Department of Health and Human Services |
| Total Award Amount |
$104,260 |
Project Location - City |
LA JOLLA |
| Award Date |
07/17/2009 |
Project Location - State |
CA |
| Project Status |
Completed |
Project Location - Zip |
92037-1005
|
| Jobs Reported |
0.00 |
Congressional District |
53 |
| Project Location - Country |
US |
|
|
Recipient Information
(Grants)
| Recipient Information (Grants) |
|
Recipient Name
|
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE |
| Recipient DUNS Number |
020520466
|
| Recipient Address |
10901 N TORREY PINES RD |
| Recipient City |
LA JOLLA |
| Recipient State |
California |
| Recipient Zip |
92037-1005 |
| Recipient Congressional District |
53 |
| Recipient Country |
USA |
Required to Report Top 5
Highly Compensated Officials |
No |
Projects and Jobs Information
| Projects and Jobs Information |
| Project Title |
Structures of membrane-bound Bcl-2 apoptotic proteins |
| Project Status |
Completed |
| Final Project Report Submitted |
Yes |
| Project Activities Description |
Medical Research, General/Other |
| Quarterly Activities/Project Description |
The overall goal of the project was to characterize the structures and interactions of the BCL-2 family proteins, the principal regulators of the mitochondrion-dependent pathway for programmed cell death or apoptosis. Their opposing pro- or anti-apoptotic activities are exerted through a network of interactions with partners within and outside the BCL-2 family, both in the cytosol and in intracellular membranes. Their associations with each other and with mitochondrial membranes have particularly important consequences for mitochondrial physiology and for cell fate. Their functions are intimately related to a large number of major human diseases (cancer, neurodegeneration, AIDS, etc.). This Supplement supported studies that are currently in progress and that are expected to yield significant results in the next few months. It provided additional funded time and resources for a senior postdoc who is working on the project, and funds to purchase new laboratory equipment. Support from this supplement has enabled us to complete and recently publish one important study regarding cell death protein-protein interactions. The work is published in the journal Biochemistry (Yong et al., 2009, Biochemistry 48:8704-8711). Recently, we have also been able to purify and obtain structral data for pro-apoptotic BAX, a protein that had been difficult to prepare. Studies on the interactions with its partners are ongoing. THe supplement has enabled us to initiate a collaboration with Don Newmeyer (La Jolla Institute for Allergy and Immunology) to examine binding of inhibitor small molecules to BAX. The additional results obtained with support of this supplement have allowed us to submit a revised renewal application for the parent grant R01GM065374 for the March 2010 deadline. |
| Jobs Created |
0.00 |
| Description of Jobs Created |
This supplement provided additional funded time and resources for one senior postdoc currently working on the project. This postdoc has been working on the project since 2006. He is highly skilled in NMR spectroscopy and biochemistry, and has extensive experience with the structural and biochemical aspects of the BCL-2 proteins. First-author publications describing his work on this project have been submitted or and one paper has been published since this supplement was funded. Without additional support this position would have had to be terminated, and he would have been forced to pursue an alternative career. The Supplement has provided additional funded time to develop the project and foster a new promising career in scinece and technology. |
Purchaser Information
(Grants)
| Purchaser Information |
| Contracting Office ID |
Not Reported |
| Contracting Office Name |
Not Available |
| Contracting Office Region |
Not Available |
| TAS Major Program |
75-0852 |
| Award Information |
| Award Date |
07/17/2009 |
| Award Number |
3 R01 GM065374-04S1 |
| Order Number |
|
| Award Type |
Grants |
| Funding Agency ID |
75 |
| Funding Agency Name |
Department of Health and Human Services |
| Funding Office Name |
Not Available |
| Awarding Agency ID |
75 |
| Awarding Agency Name |
Department of Health and Human Services |
| Amount of Award |
$104,260 |
| Funds Invoiced/Received |
$104,260 |
| Expenditure Amount |
$104,260 |
| Infrastructure Expenditure Amount |
$0 |
| Infrastructure Purpose and Rationale |
Not Reported |
| Infrastructure Point of Contact Name |
NA |
| Infrastructure Point of Contact Email |
Not Reported |
| Infrastructure Point of Contact Phone |
Not Reported |
| Infrastructure Point of Contact Address |
NA |
| Infrastructure Point of Contact City |
NA |
| Infrastructure Point of Contact State |
CA |
| Infrastructure Point of Contact Zip |
92037-1005 |
Product or Service Information
(Grants)
| Product or Service Information |
| Primary Activity Code |
H01 |
| Activity Description |
Medical Research, General/Other |
| Sub-Awards Information |
| Sub-awards to Organizations |
0 |
| Sub-award Amounts to Organizations |
$0 |
| Sub-Awards to Individuals |
0 |
| Sub-Award Amounts to Individuals |
$0 |
| Number of Sub-awards less than $25,000/award |
0 |
| Amount of Sub-awards less than $25,000/award |
$0 |
| Number of payments to vendors greater than $25,000 |
8 |
| Total Amount of payments to vendors greater than $25,000/award |
$7,525 |
| Number of payments to vendors less than $25,000/award |
16 |
| Total Amount of payments to vendors less than $25,000/award |
$7,525 |
BECKMAN INSTRUMENTS - Award Number 3 R01 GM065374-04S1 - BECKMAN INSTRUMENTS
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
60055-0164 |
| Vendor Name |
BECKMAN INSTRUMENTS |
| Product and Service Description |
MOLECULAR BIOLOGY |
| Payment Amount |
$59 |
CAMBRIDGE ISOTAPE LAB INC - Award Number 3 R01 GM065374-04S1 - CAMBRIDGE ISOTAPE LAB INC
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
01810-5413 |
| Vendor Name |
CAMBRIDGE ISOTAPE LAB INC |
| Product and Service Description |
MOLECULAR BIOLOGY |
| Payment Amount |
$3,622 |
Fisher Scientific Company LLC - Award Number 3 R01 GM065374-04S1 - Fisher Scientific Company LLC
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
90074-0129 |
| Vendor Name |
Fisher Scientific Company LLC |
| Product and Service Description |
CHEMICALS, MOLECULAR BIOLOGY |
| Payment Amount |
$98 |
INVITROGEN CORP - Award Number 3 R01 GM065374-04S1 - INVITROGEN CORP
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
92008-0000 |
| Vendor Name |
INVITROGEN CORP |
| Product and Service Description |
MOLECULAR BIOLOGY |
| Payment Amount |
$39 |
NEW ERA ENTERPRISES INC - Award Number 3 R01 GM065374-04S1 - NEW ERA ENTERPRISES INC
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
08362-0747 |
| Vendor Name |
NEW ERA ENTERPRISES INC |
| Product and Service Description |
MOLECULAR BIOLOGY |
| Payment Amount |
$142 |
SIGMA ALDRIC INC - Award Number 3 R01 GM065374-04S1 - SIGMA ALDRIC INC
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
30353-5182 |
| Vendor Name |
SIGMA ALDRIC INC |
| Product and Service Description |
CHEMICALS |
| Payment Amount |
$198 |
UCSD BOOKSTORE - SAN DIEGO - Award Number 3 R01 GM065374-04S1 - UCSD BOOKSTORE - SAN DIEGO
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
92093-0008 |
| Vendor Name |
UCSD BOOKSTORE - SAN DIEGO |
| Product and Service Description |
COMPUTER SUPPLIES, MACBOOK |
| Payment Amount |
$2,880 |
VWR International INC - Award Number 3 R01 GM065374-04S1 - VWR International INC
| Award Number |
3 R01 GM065374-04S1 |
| Sub-Award Number |
N/A |
| Vendor DUNS Number |
Not reported |
| Vendor HQ Zip Code + 4 |
91110-1257 |
| Vendor Name |
VWR International INC |
| Product and Service Description |
GLASSWARE, MOLECULAR BIOLOGY |
| Payment Amount |
$488 |
| Location Information |
| Latitude, Longitude |
32º 52' 13",
-117º 14' 50" |
| Congressional District |
53 |
| Address 1 |
10901 N. TORREY PINES ROAD |
| Address 2 |
|
| City |
LA JOLLA |
| County |
San Diego |
| State |
CA |
| Zip |
92037-1005 |
|
 |