UNIVERSITY OF MASSACHUSETTS
This award is designed to investigate the role of protein kinase C epsilon (PKCe) in the antiadrenergic action of adenosine. The antiadrenergic action of adenosine via adenosine A1 receptors limits the responsiveness of the heart to beta-adrenergic nerve stimulation in the normal, ischemic and aging heart. PKCe is important in the signal transduction of adenosine A1 receptors which are activated by myocardial adenosine. The information garnered from this project will lead to the development of cardiac agents and therapies that should help to alleviate heart failure.