Grants - AWARD SUMMARY


UNIVERSITY OF MASSACHUSETTS


This award is designed to investigate the role of protein kinase C epsilon (PKCe) in the antiadrenergic action of adenosine. The antiadrenergic action of adenosine via adenosine A1 receptors limits the responsiveness of the heart to beta-adrenergic nerve stimulation in the normal, ischemic and aging heart. PKCe is important in the signal transduction of adenosine A1 receptors which are activated by myocardial adenosine. The information garnered from this project will lead to the development of cardiac agents and therapies that should help to alleviate heart failure.

Clarification of Codes

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AWARD OVERVIEW

AWARD OVERVIEW
Award Number 3R01HL084160-02S1 Funding Agency Department of Health and Human Services
Total Award Amount $283,291 Project Location - City Worcester
Award Date 07/16/2009 Project Location - State MA
Project Status Completed Project Location - Zip 01655-0002
Jobs Reported 1.20 Congressional District 03
Project Location - Country US

Recipient Information (Grants)

Recipient Information (Grants)
Recipient Name UNIVERSITY OF MASSACHUSETTS
Recipient DUNS Number 603847393
Recipient Address 55 LAKE AVE N
Recipient City WORCESTER
Recipient State Massachusetts
Recipient Zip 01655-0002
Recipient Congressional District 03
Recipient Country USA
Required to Report Top 5
Highly Compensated Officials		 No

Projects and Jobs Information

Projects and Jobs Information
Project Title Myocardial Adenosine Receptors
Project Status Completed
Final Project Report Submitted Yes
Project Activities Description Heart Diseases Research
Quarterly Activities/Project Description Final experiments have been conducted investigating the effects of adenosine and adrenergic agent stimulation of mammalian ventricular cardiomyocytes on the activity and translocation of PKC epsilon. In our investigation of the effect of adenosine on p42 MAPK and the involvement of PKC epsilon, it became apparent that adrenergic stimulation was in some manner affecting the primary stimulation. These studies are revealing a complex interaction in the heart between adenosine and catecholamine stimulation at the level of PKC epsilon. Final data reduction is being conducted and manuscript preparation is being initiated to report these findings. In last quarter of this project Western blotting techniques were performed to comfirm our earlier findings. A manuscript has been perpared and is ready for submission dealing with his important findings. The final invoicing for the project will be complete in the next couple weeks.
Jobs Created 1.20
Description of Jobs Created 2 Assoc Professors, Research Associate I


Purchaser Information (Grants)

Purchaser Information
Contracting Office ID Not Reported
Contracting Office Name Not Available
Contracting Office Region Not Available
TAS Major Program 75-0871

Award Information

Award Information
Award Date 07/16/2009
Award Number 3R01HL084160-02S1
Order Number
Award Type Grants
Funding Agency ID 75
Funding Agency Name Department of Health and Human Services
Funding Office Name Not Available
Awarding Agency ID 75
Awarding Agency Name Department of Health and Human Services
Amount of Award $283,291
Funds Invoiced/Received $277,913
Expenditure Amount $277,913
Infrastructure Expenditure Amount $0
Infrastructure Purpose and Rationale Not Reported
Infrastructure Point of Contact Name Not Reported
Infrastructure Point of Contact Email Not Reported
Infrastructure Point of Contact Phone Not Reported
Infrastructure Point of Contact Address Not Reported
Infrastructure Point of Contact City Not Reported
Infrastructure Point of Contact State Not Reported
Infrastructure Point of Contact Zip Not Reported

Product or Service Information (Grants)

Product or Service Information
Primary Activity Code H02.05.02
Activity Description Heart Diseases Research

Sub-Awards Information

Sub-Awards Information
Sub-awards to Organizations 0
Sub-award Amounts to Organizations $0
Sub-Awards to Individuals 0
Sub-Award Amounts to Individuals $0
Number of Sub-awards less than $25,000/award 0
Amount of Sub-awards less than $25,000/award $0
Number of payments to vendors greater than $25,000 0
Total Amount of payments to vendors greater than $25,000/award $0
Number of payments to vendors less than $25,000/award 137
Total Amount of payments to vendors less than $25,000/award $29,182







Project Location Detail

Location Information
Latitude, Longitude 42º 16' 39", -71º 45' 33"
Congressional District 03
Address 1 55 Lake Avenue North
Address 2
City Worcester
County Worcester
State MA
Zip 01655-0002
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